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Tbio
NT5C3B
7-methylguanosine phosphate-specific 5'-nucleotidase

Protein Summary
Description
Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000435506
  • ENSP00000389948
  • ENSG00000141698

Symbol
  • NT5C3L
  • NT5C3L
  • cN-IIIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor perturbation
0.8
molecular function
0.67
tissue sample
0.66
cell type or tissue
0.63


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
NT5C1B
Tbio
Family:  Enzyme
Novelty:  0.09140009
Score:  0.945
Data Source:  STRINGDB
NT5C1A
Tbio
Family:  Enzyme
Novelty:  0.00634411
Score:  0.944
Data Source:  STRINGDB
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
Score:  0.939
Data Source:  STRINGDB
CMPK2
Tbio
Family:  Kinase
Novelty:  0.01285082
Score:  0.922
Data Source:  STRINGDB
PNP
Tclin
Family:  Enzyme
Novelty:  0.0019084
Score:  0.92
Data Source:  STRINGDB
NT5C2
Tbio
Family:  Enzyme
Novelty:  0.00758288
Score:  0.918
Data Source:  STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.917
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.916
Data Source:  STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.915
Data Source:  STRINGDB
NT5M
Tchem
Family:  Enzyme
Novelty:  0.03299091
Score:  0.915
Data Source:  STRINGDB
Nearest Tclin Targets (32)
Explore Nearest Tclin Targets
1 – 5 of 26
TYMS
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE1C
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE10A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE6D
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (10)
Deadenylation-dependent mRNA decay (R-HSA-429914)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
mRNA decay by 3' to 5' exoribonuclease
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
mRNA decay by 3' to 5' exoribonuclease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
5
7
96.5
reticulocyte measurement
3
3
4
94.7
heel bone mineral density
3
2
4
78.7
balding measurement
1
1
1
64.4
eosinophil count
2
1
2
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
96.5
reticulocyte measurement
4
94.7
heel bone mineral density
4
78.7
balding measurement
1
64.4
eosinophil count
2
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5'-nucleotidase, cytosolic IIIB
VGNC:9484
743177
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5'-nucleotidase, cytosolic IIIB
Publication Statistics
PubMed Score 5.67
PubMed score by year
PubTator Score 1.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title