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Tbio
NT5C2
Cytosolic purine 5'-nucleotidase

Protein Summary
Description
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343289
  • ENSP00000339479
  • ENSG00000076685
  • ENST00000404739
  • ENSP00000383960

Symbol
  • NT5B
  • NT5CP
  • PNT5
  • GMP
  • NT5B
  • PNT5
  • SPG45
  • SPG65
  • cN-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
molecular function
0.81
microRNA
0.72
kinase perturbation
0.71
transcription factor
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.48   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.48   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (169)
HSPBP1
Tbio
Novelty:  0.01176285
p_int:  0.999999979
p_ni:  1e-8
p_wrong:  1.1e-8
Score:  0.382
Data Source:  BioPlex,STRINGDB
ZBTB24
Tbio
Family:  TF
Novelty:  0.041401
p_int:  0.999999921
p_ni:  7.9e-8
Data Source:  BioPlex
SNX15
Tdark
Novelty:  0.27466573
p_int:  0.999999795
p_ni:  2.05e-7
Score:  0.692
Data Source:  BioPlex,STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.968
Data Source:  STRINGDB
NT5C1A
Tbio
Family:  Enzyme
Novelty:  0.00634411
Score:  0.956
Data Source:  STRINGDB
DCTD
Tbio
Family:  Enzyme
Novelty:  0.02275597
Score:  0.954
Data Source:  STRINGDB
NT5C3A
Tbio
Family:  Enzyme
Novelty:  0.01939545
Score:  0.952
Data Source:  STRINGDB
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
Score:  0.945
Data Source:  STRINGDB
PNP
Tclin
Family:  Enzyme
Novelty:  0.0019084
Score:  0.945
Data Source:  STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.937
Data Source:  STRINGDB
Nearest Tclin Targets (32)
Explore Nearest Tclin Targets
1 – 5 of 26
TYMS
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE1B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE6A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE3B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (17)
Abacavir metabolism (R-HSA-2161541)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abacavir metabolism
Reactome
Abacavir transport and metabolism
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Name
Explore in Pharos
Explore in Source
Abacavir metabolism
Abacavir transport and metabolism
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
3
6
97.8
reticulocyte measurement
3
2
3
95.6
11
10
3
1.2
94.2
2
5
6
90.4
smoking behavior
1
3
3
89.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
97.8
reticulocyte measurement
3
95.6
3
1.2
94.2
6
90.4
smoking behavior
3
89.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5'-nucleotidase, cytosolic II
450706
Macaque
5'-nucleotidase, cytosolic II
714292
Mouse
MGI:2178563
76952
Dog
5'-nucleotidase, cytosolic II
VGNC:43996
477809
Horse
5'-nucleotidase, cytosolic II
VGNC:20913
100069793
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5'-nucleotidase, cytosolic II
Macaque
5'-nucleotidase, cytosolic II
Mouse
Dog
5'-nucleotidase, cytosolic II
Horse
5'-nucleotidase, cytosolic II
Publication Statistics
PubMed Score 142.48
PubMed score by year
PubTator Score 797.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title