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Tbio
NT5C1A
Cytosolic 5'-nucleotidase 1A

Protein Summary
Description
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia. Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000235628
  • ENSP00000235628
  • ENSG00000116981

Symbol
  • CN1
  • CNI
  • CN-I
  • CN1A
  • CN-IA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.66
molecular function
0.63
cell line
0.61
biological process
0.5
metabolite
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.69   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.69   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
ICAM1
Tchem
Novelty:  0.00009746
p_int:  0.992274969
p_ni:  0.001808786
p_wrong:  0.005916245
Score:  0.187
Data Source:  BioPlex,STRINGDB
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.989099946
p_ni:  0.000476237
p_wrong:  0.010423817
Score:  0.167
Data Source:  BioPlex,STRINGDB
NT5C2
Tbio
Family:  Enzyme
Novelty:  0.00758288
Score:  0.956
Data Source:  STRINGDB
NT5C3A
Tbio
Family:  Enzyme
Novelty:  0.01939545
Score:  0.944
Data Source:  STRINGDB
NT5C3B
Tbio
Family:  Enzyme
Novelty:  0.20743662
Score:  0.944
Data Source:  STRINGDB
NT5C
Tbio
Family:  Enzyme
Novelty:  0.00686933
Score:  0.944
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.937
Data Source:  STRINGDB
NT5M
Tchem
Family:  Enzyme
Novelty:  0.03299091
Score:  0.933
Data Source:  STRINGDB
ATIC
Tchem
Novelty:  0.00466845
Score:  0.932
Data Source:  STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.932
Data Source:  STRINGDB
Nearest Tclin Targets (32)
Explore Nearest Tclin Targets
1 – 5 of 26
TYMS
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
IMPDH1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE4A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
IMPDH2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Purine catabolism
Reactome
Pyrimidine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Purine catabolism
Pyrimidine catabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
6
13
98.5
apolipoprotein A 1 measurement
2
2
2
93.9
C-reactive protein measurement
4
3
4
91.7
mean corpuscular hemoglobin concentration
1
1
1
83.6
red blood cell distribution width
3
1
3
83.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
13
98.5
apolipoprotein A 1 measurement
2
93.9
C-reactive protein measurement
4
91.7
mean corpuscular hemoglobin concentration
1
83.6
red blood cell distribution width
3
83.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5'-nucleotidase, cytosolic IA
469289
Mouse
MGI:2155700
230718
Rat
RGD:1310908
313574
Dog
5'-nucleotidase, cytosolic IA
VGNC:43995
482463
Horse
5'-nucleotidase, cytosolic IA
VGNC:20912
100054191
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5'-nucleotidase, cytosolic IA
Mouse
Rat
Dog
5'-nucleotidase, cytosolic IA
Horse
5'-nucleotidase, cytosolic IA
Publication Statistics
PubMed Score 171.69
PubMed score by year
PubTator Score 240.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title