Tbio NT5C1A Cytosolic 5'-nucleotidase 1A

Protein Summary

Description

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia. Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9BXI3
• Q3SYB9
• Q5TG98
• Q9BWT8
• cN1A

Gene Name

• NT5C1A

Ensembl ID

• ENST00000235628
• ENSP00000235628
• ENSG00000116981

Symbol

• CN1
• CNI
• CN-I
• CN1A
• CN-IA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.66
molecular function	0.63
cell line	0.61
biological process	0.5
metabolite	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.02   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.02   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0