NT5C
5'(3')-deoxyribonucleotidase, cytosolic type
Protein Summary
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
- ENST00000245552
- ENSP00000245552
- ENSG00000125458
- ENST00000580758
- ENSP00000462123
- DNT1
- UMPH2
- DNT
- cdN
- DNT1
- P5N2
- PN-I
- HEL74
- PN-II
- UMPH2
- dNT-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.83 | ||
cell type or tissue | 0.69 | ||
cell line | 0.65 | ||
molecular function | 0.63 | ||
tissue | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 308.4 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 75 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 308.4 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 75 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0