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Tbio
NSUN5
Probable 28S rRNA (cytosine-C(5))-methyltransferase

Protein Summary
Description
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA. This gene encodes a member of an evolutionarily conserved family of proteins that may function as methyltransferases. This gene is located in a larger region of chromosome 7 that is deleted in Williams-Beuren syndrome, a multisystem developmental disorder. There are two pseudogenes for this gene located in the same region of chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252594
  • ENSP00000252594
  • ENSG00000130305
  • ENST00000310326
  • ENSP00000309126
  • ENST00000428206
  • ENSP00000393081
  • ENST00000438747
  • ENSP00000388464

Symbol
  • NSUN5A
  • WBSCR20
  • WBSCR20A
  • NOL1
  • p120
  • NOL1R
  • NSUN5A
  • WBSCR20
  • WBSCR20A
  • p120(NOL1)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
interacting protein
0.86
virus perturbation
0.85
tissue sample
0.66
gene perturbation
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.09   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.09   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0