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Tbio
NSUN5
Probable 28S rRNA (cytosine-C(5))-methyltransferase

Protein Summary
Description
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA. This gene encodes a member of an evolutionarily conserved family of proteins that may function as methyltransferases. This gene is located in a larger region of chromosome 7 that is deleted in Williams-Beuren syndrome, a multisystem developmental disorder. There are two pseudogenes for this gene located in the same region of chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252594
  • ENSP00000252594
  • ENSG00000130305
  • ENST00000310326
  • ENSP00000309126
  • ENST00000428206
  • ENSP00000393081
  • ENST00000438747
  • ENSP00000388464

Symbol
  • NSUN5A
  • WBSCR20
  • WBSCR20A
  • NOL1
  • p120
  • NOL1R
  • NSUN5A
  • WBSCR20
  • WBSCR20A
  • p120(NOL1)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
interacting protein
0.86
virus perturbation
0.85
tissue sample
0.66
gene perturbation
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.92   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.92   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (140)
NSUN5P1
Tdark
Family:  Enzyme
p_int:  1
Data Source:  BioPlex
ZNF609
Tdark
Novelty:  0.06635612
p_int:  0.98994893
p_ni:  0.010038692
p_wrong:  0.000012379
Data Source:  BioPlex
ZNF653
Tbio
Family:  TF
Novelty:  1.467544
p_int:  0.98924287
p_ni:  0.010757129
p_wrong:  1e-9
Data Source:  BioPlex
MAP2K1
Tclin
Family:  Kinase
Novelty:  0.0005278
p_int:  0.96617732
p_ni:  0.033817308
p_wrong:  0.000005371
Data Source:  BioPlex
FAM171A2
Tdark
Novelty:  1.18763693
p_int:  0.87641884
p_ni:  0.12355018
p_wrong:  0.00003098
Data Source:  BioPlex
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.829277807
p_ni:  0.170722193
Score:  0.195
Data Source:  BioPlex,STRINGDB
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.815026462
p_ni:  0.184956931
p_wrong:  0.000016607
Data Source:  BioPlex
SALL2
Tbio
Family:  TF
Novelty:  0.01181421
p_int:  0.772108991
p_ni:  0.227890421
p_wrong:  5.87e-7
Data Source:  BioPlex
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.981
Data Source:  STRINGDB
NSUN3
Tbio
Family:  Enzyme
Novelty:  0.15268529
Score:  0.866
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
2
2
60.8
body height
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
60.8
body height
1
46.1
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NOP2/Sun RNA methyltransferase family member 5
716219
Mouse
MGI:2140844
100609
Rat
RGD:1309268
288595
Dog
NOP2/Sun RNA methyltransferase family member 5
479720
Horse
NOP2/Sun RNA methyltransferase family member 5
VGNC:51198
100061362
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NOP2/Sun RNA methyltransferase family member 5
Mouse
Rat
Dog
NOP2/Sun RNA methyltransferase family member 5
Horse
NOP2/Sun RNA methyltransferase family member 5
Publication Statistics
PubMed Score 19.92
PubMed score by year
PubTator Score 3.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title