You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NSUN4
5-methylcytosine rRNA methyltransferase NSUN4

Protein Summary
Description
Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000474844
  • ENSP00000419740
  • ENSG00000117481
  • ENST00000537428
  • ENSP00000437758

Symbol
  • SHTAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
kinase perturbation
0.91
transcription factor binding site profile
0.86
tissue sample
0.69
cellular component
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.15   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.15   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (203)
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.999997586
p_ni:  0.000002414
Score:  0.157
Data Source:  BioPlex,STRINGDB
MND1
Tbio
Novelty:  0.02206181
p_int:  0.999939673
p_ni:  0.000060325
p_wrong:  2e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
CA10
Tbio
Family:  Enzyme
Novelty:  0.01053152
p_int:  0.99979879
p_ni:  0.000201193
p_wrong:  1.7e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
SSMEM1
Tdark
Novelty:  1.77966102
p_int:  0.999684156
p_ni:  0.00031521
p_wrong:  6.33e-7
Score:  0.181
Data Source:  BioPlex,STRINGDB
INSL3
Tbio
Novelty:  0.00374656
p_int:  0.999679967
p_ni:  0.000320029
p_wrong:  4e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.997602143
p_ni:  0.002397856
p_wrong:  1e-9
Score:  0.236
Data Source:  BioPlex,STRINGDB
AURKAIP1
Tchem
Family:  Enzyme
Novelty:  0.19241693
p_int:  0.997042713
p_ni:  0.002886208
p_wrong:  0.000071078
Score:  0.499
Data Source:  BioPlex,STRINGDB
DENR
Tbio
Novelty:  0.00653432
p_int:  0.99699394
p_ni:  0.00300604
p_wrong:  2.1e-8
Data Source:  BioPlex
RPL13
Tbio
Novelty:  0.0159486
p_int:  0.994421013
p_ni:  0.005578031
p_wrong:  9.56e-7
Score:  0.39
Data Source:  BioPlex,STRINGDB
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.987744111
p_ni:  0.012255889
Score:  0.344
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
rRNA modification in the mitochondrion
Reactome
rRNA processing
Reactome
rRNA processing in the mitochondrion
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
rRNA modification in the mitochondrion
rRNA processing
rRNA processing in the mitochondrion
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
N-acylethanolamine measurement
1
1
5
44.2
age at menopause
1
1
1
27.3
BMI-adjusted hip circumference
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
N-acylethanolamine measurement
5
44.2
age at menopause
1
27.3
BMI-adjusted hip circumference
1
24.5
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NOP2/Sun RNA methyltransferase family member 4
708078
Mouse
MGI:1919431
72181
Rat
RGD:1559652
298426
Dog
NOP2/Sun RNA methyltransferase family member 4
VGNC:54217
610446
Horse
NOP2/Sun RNA methyltransferase family member 4
VGNC:50734
100051817
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NOP2/Sun RNA methyltransferase family member 4
Mouse
Rat
Dog
NOP2/Sun RNA methyltransferase family member 4
Horse
NOP2/Sun RNA methyltransferase family member 4
Publication Statistics
PubMed Score 7.15
PubMed score by year
PubTator Score 1.98
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title