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Tdark
NSMCE4A
Non-structural maintenance of chromosomes element 4 homolog A

Protein Summary
Description
Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369017
  • ENSP00000358013
  • ENSG00000107672
  • ENST00000369023
  • ENSP00000358019

Symbol
  • C10orf86
  • NS4EA
  • NSE4A
  • C10orf86
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase perturbation
0.81
histone modification site profile
0.76
disease perturbation
0.68
tissue sample
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.62   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.62   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
NSMCE1
Tdark
Novelty:  0.75370409
p_int:  1
Score:  0.995
Data Source:  BioPlex,STRINGDB
NSMCE3
Tbio
Novelty:  0.04335295
p_int:  0.999999904
p_ni:  9.6e-8
Score:  0.996
Data Source:  BioPlex,STRINGDB
ZNF597
Tbio
Family:  TF
Novelty:  0.04420398
p_int:  0.999998876
p_ni:  0.000001123
Score:  0.836
Data Source:  BioPlex,STRINGDB
SMC6
Tbio
Novelty:  0.02450073
p_int:  0.997547505
p_ni:  0.002452494
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
ARNTL2
Tbio
Family:  TF
Novelty:  0.0039351
p_int:  0.99707488
p_ni:  0.002925119
p_wrong:  1e-9
Data Source:  BioPlex
DNAJB2
Tbio
Novelty:  0.046216
p_int:  0.992873702
p_ni:  0.007126298
Data Source:  BioPlex
SMC5
Tbio
Novelty:  0.008623
p_int:  0.990173727
p_ni:  0.009826221
p_wrong:  5.2e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
PJA1
Tbio
Family:  Enzyme
Novelty:  0.06148437
p_int:  0.986767746
p_ni:  0.013232248
p_wrong:  6e-9
Score:  0.79
Data Source:  BioPlex,STRINGDB
CCDC151
Tbio
Novelty:  0.15952702
p_int:  0.983578316
p_ni:  0.013865862
p_wrong:  0.002555822
Data Source:  BioPlex
IER2
Tbio
Novelty:  0.03864806
p_int:  0.980484622
p_ni:  0.019515367
p_wrong:  1.1e-8
Score:  0.213
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of DNA damage response and repair proteins
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of DNA damage response and repair proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
5
86.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
86.6
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NSE4 homolog A, SMC5-SMC6 complex component
VGNC:5584
742274
Macaque
NSE4 homolog A, SMC5-SMC6 complex component
705375
Mouse
MGI:1915122
67872
Dog
NSE4 homolog A, SMC5-SMC6 complex component
VGNC:53004
477849
Horse
NSE4 homolog A, SMC5-SMC6 complex component
VGNC:20907
100064829
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NSE4 homolog A, SMC5-SMC6 complex component
Macaque
NSE4 homolog A, SMC5-SMC6 complex component
Mouse
Dog
NSE4 homolog A, SMC5-SMC6 complex component
Horse
NSE4 homolog A, SMC5-SMC6 complex component
Publication Statistics
PubMed Score 2.62
PubMed score by year
PubTator Score 0.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title