You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
NSMCE1
Non-structural maintenance of chromosomes element 1 homolog

Protein Summary
Description
RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair (PubMed:29225034, PubMed:20864041). NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair (PubMed:18086888). MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361439
  • ENSP00000355077
  • ENSG00000169189

Symbol
  • NSE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
histone modification site profile
0.91
transcription factor binding site profile
0.85
disease perturbation
0.83
kinase perturbation
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.93   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.93   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
NSMCE4A
Tdark
Novelty:  0.45550673
p_int:  1
Score:  0.995
Data Source:  BioPlex,STRINGDB
SMC5
Tbio
Novelty:  0.008623
p_int:  0.999999997
p_ni:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
SMC6
Tbio
Novelty:  0.02450073
p_int:  0.999999956
p_ni:  4.3e-8
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
MAGEB10
Tdark
Novelty:  2.96156972
p_int:  0.999999946
p_ni:  5.4e-8
Score:  0.435
Data Source:  BioPlex,STRINGDB
NSMCE3
Tbio
Novelty:  0.04335295
p_int:  0.999999944
p_ni:  5.5e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
NSMCE2
Tbio
Family:  Enzyme
Novelty:  0.02320995
p_int:  0.999999757
p_ni:  2.3e-8
p_wrong:  2.2e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZNF597
Tbio
Family:  TF
Novelty:  0.04420398
p_int:  0.999999622
p_ni:  3.42e-7
p_wrong:  3.6e-8
Score:  0.865
Data Source:  BioPlex,STRINGDB
EID3
Tdark
Novelty:  0.37412011
p_int:  0.999999385
p_ni:  6.15e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
SLF2
Tbio
Novelty:  0.08944991
p_int:  0.99999096
p_ni:  1.69e-7
p_wrong:  0.000008871
Score:  0.527
Data Source:  BioPlex,STRINGDB
SIMC1
Tbio
Novelty:  0.39770049
p_int:  0.999420055
p_ni:  0.000579945
Score:  0.167
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of DNA damage response and repair proteins
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of DNA damage response and repair proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
4
5
96.4
5
6
0
1.1
91.8
eosinophil percentage of leukocytes
2
3
3
91.8
childhood onset asthma
2
1
0
1.1
77.9
Inhalant adrenergic use measurement
1
2
2
71.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
96.4
0
1.1
91.8
eosinophil percentage of leukocytes
3
91.8
childhood onset asthma
0
1.1
77.9
Inhalant adrenergic use measurement
2
71.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NSE1 homolog, SMC5-SMC6 complex component
VGNC:5852
454004
Mouse
MGI:1914961
67711
Rat
RGD:1307760
361645
Dog
NSE1 homolog, SMC5-SMC6 complex component
VGNC:43988
479800
Horse
NSE1 homolog, SMC5-SMC6 complex component
VGNC:20905
100066837
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NSE1 homolog, SMC5-SMC6 complex component
Mouse
Rat
Dog
NSE1 homolog, SMC5-SMC6 complex component
Horse
NSE1 homolog, SMC5-SMC6 complex component
Publication Statistics
PubMed Score 1.93
PubMed score by year
PubTator Score 6.39
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title