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Tbio
NSMAF
Protein FAN

Protein Summary
Description
Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE. This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000038176
  • ENSP00000038176
  • ENSG00000035681
  • ENST00000427130
  • ENSP00000411012

Symbol
  • FAN
  • FAN
  • GRAMD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
disease perturbation
0.9
transcription factor perturbation
0.88
interacting protein
0.86
protein domain
0.85


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.05   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.05   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
HEXIM1
Tbio
Novelty:  0.0142443
p_int:  0.999818449
p_ni:  0.000155823
p_wrong:  0.000025729
Score:  0.27
Data Source:  BioPlex,STRINGDB
HEPHL1
Tbio
Novelty:  0.44678065
p_int:  0.999749473
p_ni:  0.00024951
p_wrong:  0.000001017
Data Source:  BioPlex
LYG2
Tbio
Family:  Enzyme
Novelty:  0.12091256
p_int:  0.998757442
p_ni:  0.001242554
p_wrong:  3e-9
Data Source:  BioPlex
PREP
Tchem
Family:  Enzyme
Novelty:  0.00148266
p_int:  0.998699401
p_ni:  0.001300599
Score:  0.267
Data Source:  BioPlex,STRINGDB
SELENBP1
Tbio
Novelty:  0.00758018
p_int:  0.996483994
p_ni:  0.003516006
Data Source:  BioPlex
GABARAPL1
Tbio
Novelty:  0.00212657
p_int:  0.992717692
p_ni:  0.000001531
p_wrong:  0.007280777
Score:  0.492
Data Source:  BioPlex,STRINGDB
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.990395087
p_ni:  0.009604913
Data Source:  BioPlex
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.974522582
p_ni:  0.025476958
p_wrong:  4.6e-7
Score:  0.158
Data Source:  BioPlex,STRINGDB
TCHH
Tbio
Novelty:  0.00303837
p_int:  0.961598369
p_ni:  0.000070362
p_wrong:  0.03833127
Score:  0.219
Data Source:  BioPlex,STRINGDB
PKP3
Tbio
Novelty:  0.0269462
p_int:  0.958432864
p_ni:  0.041566796
p_wrong:  3.41e-7
Data Source:  BioPlex
Pathways (9)
Death Receptor Signalling (R-HSA-73887)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Signal Transduction
Reactome
TNF signaling
Reactome
TNFR1-mediated ceramide production
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Signal Transduction
TNF signaling
TNFR1-mediated ceramide production
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
78.6
total cholesterol measurement
1
1
1
75
apolipoprotein B measurement
1
1
1
68.6
triglyceride measurement
1
1
1
59.6
IGF-1 measurement
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
78.6
total cholesterol measurement
1
75
apolipoprotein B measurement
1
68.6
triglyceride measurement
1
59.6
IGF-1 measurement
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neutral sphingomyelinase activation associated factor
VGNC:1163
464193
Macaque
protein FAN
698508
Mouse
MGI:1341864
18201
Rat
RGD:727868
353233
Dog
neutral sphingomyelinase activation associated factor
VGNC:43987
477892
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neutral sphingomyelinase activation associated factor
Macaque
protein FAN
Mouse
Rat
Dog
neutral sphingomyelinase activation associated factor
Publication Statistics
PubMed Score 9.05
PubMed score by year
PubTator Score 66.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title