You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NSFL1C
NSFL1 cofactor p47

Protein Summary
Description
Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216879
  • ENSP00000216879
  • ENSG00000088833
  • ENST00000353088
  • ENSP00000338643
  • ENST00000476071
  • ENSP00000418529

Symbol
  • UBXN2C
  • P47
  • UBX1
  • UBXD10
  • UBXN2C
  • dJ776F14.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
transcription factor binding site profile
0.93
transcription factor
0.75
tissue
0.69
microRNA
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.77   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.77   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
FGGY
Tbio
Family:  Kinase
Novelty:  0.05162577
p_int:  0.999999996
p_wrong:  4e-9
Score:  0.504
Data Source:  BioPlex,STRINGDB
ASPSCR1
Tbio
Novelty:  0.01172319
p_int:  0.999998564
p_ni:  0.000001436
Score:  0.874
Data Source:  BioPlex,STRINGDB
VCP
Tchem
Family:  Enzyme
Novelty:  0.00103317
p_int:  0.999983546
p_ni:  0.000016454
Score:  0.999
Data Source:  BioPlex,STRINGDB
UBXN6
Tbio
Novelty:  0.08383376
Score:  0.972
Data Source:  STRINGDB
UFD1
Tbio
Novelty:  0.01230296
Score:  0.929
Data Source:  STRINGDB
NPLOC4
Tbio
Novelty:  0.01690434
Score:  0.919
Data Source:  STRINGDB
PLAA
Tchem
Family:  Enzyme
Novelty:  0.01164687
Score:  0.882
Data Source:  STRINGDB
VCPIP1
Tbio
Novelty:  0.09915033
Score:  0.86
Data Source:  STRINGDB
SVIP
Tbio
Novelty:  0.05269453
Score:  0.851
Data Source:  STRINGDB
STX5
Tbio
Novelty:  0.00964918
Score:  0.84
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
84.4
glomerular filtration rate
2
2
2
74.1
platelet crit
1
1
1
64.9
neutrophil count
2
1
2
44.2
leukocyte count
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
84.4
glomerular filtration rate
2
74.1
platelet crit
1
64.9
neutrophil count
2
44.2
leukocyte count
1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NSFL1 cofactor
VGNC:10156
469859
Macaque
NSFL1 cofactor
715743
Mouse
MGI:3042273
386649
Rat
RGD:619952
83809
Dog
NSFL1 cofactor
VGNC:43984
100685961
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NSFL1 cofactor
Macaque
NSFL1 cofactor
Mouse
Rat
Dog
NSFL1 cofactor
Publication Statistics
PubMed Score 16.77
PubMed score by year
PubTator Score 6.72
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title