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Tbio
NSF
Vesicle-fusing ATPase

Protein Summary
Description
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398238
  • ENSP00000381293
  • ENSG00000073969
  • ENST00000611398
  • ENSP00000478614
  • ENSG00000278174
  • ENST00000620290
  • ENSP00000481714
  • ENSG00000276262

Symbol
  • SKD2
  • SEC18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
1
protein domain
0.97
disease perturbation
0.87
biological process
0.84


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 769.22   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 769.22   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0