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Tbio
NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific

Protein Summary
Description
Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347982
  • ENSP00000343209
  • ENSG00000165671
  • ENST00000354179
  • ENSP00000346111
  • ENST00000439151
  • ENSP00000395929

Symbol
  • ARA267
  • KMT3B
  • STO
  • KMT3B
  • SOTOS
  • ARA267
  • SOTOS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
virus perturbation
0.98
disease perturbation
0.96
transcription factor
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.22   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.22   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (137)
ZFY
Tdark
Family:  TF
p_int:  0.999974774
p_ni:  0.000025221
p_wrong:  5e-9
Data Source:  BioPlex
ZBTB48
Tbio
Family:  TF
Novelty:  0.07020518
p_int:  0.999638733
p_ni:  0.000361267
Score:  0.281
Data Source:  BioPlex,STRINGDB
ZNF653
Tbio
Family:  TF
Novelty:  1.467544
p_int:  0.999563927
p_ni:  0.000435213
p_wrong:  8.6e-7
Score:  0.152
Data Source:  BioPlex,STRINGDB
ZNF692
Tbio
Family:  TF
Novelty:  0.07012646
p_int:  0.999383438
p_ni:  0.000616562
Score:  0.282
Data Source:  BioPlex,STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.997764849
p_ni:  0.002235151
Score:  0.381
Data Source:  BioPlex,STRINGDB
PLOD1
Tbio
Family:  Enzyme
Novelty:  0.00905345
Score:  0.781
Data Source:  STRINGDB
KDM2A
Tchem
Family:  Epigenetic
Novelty:  0.01990727
Score:  0.753
Data Source:  STRINGDB
ZNF496
Tbio
Family:  TF
Novelty:  0.18264818
Score:  0.752
Data Source:  STRINGDB
CAMKMT
Tbio
Family:  Enzyme
Novelty:  0.00382649
Score:  0.751
Data Source:  STRINGDB
NUP98
Tbio
Family:  Enzyme
Novelty:  0.00401452
Score:  0.731
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (58)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
9
12
15.2
99.3
creatinine measurement
5
7
8
97
BMI-adjusted waist circumference
7
16
41
97
BMI-adjusted waist-hip ratio
11
9
19
96.2
waist-hip ratio
3
10
13
96.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
12
15.2
99.3
creatinine measurement
8
97
BMI-adjusted waist circumference
41
97
BMI-adjusted waist-hip ratio
19
96.2
waist-hip ratio
13
96.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor binding SET domain protein 1
VGNC:6953
471754
Macaque
nuclear receptor binding SET domain protein 1
706131
Mouse
MGI:1276545
18193
Rat
RGD:1307748
306764
Dog
nuclear receptor binding SET domain protein 1
VGNC:43980
489094
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor binding SET domain protein 1
Macaque
nuclear receptor binding SET domain protein 1
Mouse
Rat
Dog
nuclear receptor binding SET domain protein 1
Publication Statistics
PubMed Score 227.22
PubMed score by year
PubTator Score 175.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title