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Tbio
NRROS
Transforming growth factor beta activator LRRC33

Protein Summary
Description
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (By similarity). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1 (By similarity). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS (By similarity). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (PubMed:23545260).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328557
  • ENSP00000328625
  • ENSG00000174004

Symbol
  • LRRC33
  • GARPL1
  • LRRC33
  • UNQ3030
  • ELLP3030
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.7
transcription factor binding site profile
0.54
transcription factor perturbation
0.54
histone modification site profile
0.51
gene perturbation
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.99   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.99   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
MARK3
Tchem
Family:  Kinase
Novelty:  0.01304552
p_int:  0.999974347
p_ni:  0.000025653
Score:  0.185
Data Source:  BioPlex,STRINGDB
MARK2
Tchem
Family:  Kinase
Novelty:  0.00437762
p_int:  0.999843328
p_ni:  0.000156672
Score:  0.189
Data Source:  BioPlex,STRINGDB
CNPY3
Tbio
Novelty:  0.11473132
p_int:  0.998750809
p_ni:  0.001249191
Score:  0.165
Data Source:  BioPlex,STRINGDB
RTN4RL2
Tbio
Novelty:  0.05919593
p_int:  0.994532172
p_ni:  0.000722031
p_wrong:  0.004745797
Score:  0.195
Data Source:  BioPlex,STRINGDB
NDST1
Tbio
Family:  Enzyme
Novelty:  0.00955868
p_int:  0.99048657
p_ni:  0.008351632
p_wrong:  0.001161798
Score:  0.189
Data Source:  BioPlex,STRINGDB
CANX
Tbio
Novelty:  0.00087002
p_int:  0.977306423
p_ni:  0.022693577
Data Source:  BioPlex
LINGO1
Tbio
Novelty:  0.00778085
p_int:  0.977146955
p_ni:  0.022851985
p_wrong:  0.000001061
Data Source:  BioPlex
TGFB1
Tbio
Novelty:  0.0001299
p_int:  0.962863453
p_ni:  0.037136547
Score:  0.273
Data Source:  BioPlex,STRINGDB
ITPRIP
Tbio
Novelty:  0.27051709
p_int:  0.932414697
p_ni:  0.067585303
Score:  0.153
Data Source:  BioPlex,STRINGDB
NDUFA3
Tclin
Family:  Enzyme
Novelty:  0.21111937
p_int:  0.925189218
p_ni:  0.074810756
p_wrong:  2.6e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
6
4
0
1.1
92
allergic disease
2
2
0
1.1
80.4
eosinophil count
3
2
3
76.4
eosinophil percentage of leukocytes
1
1
1
60.5
Eczema
2
2
0
1.1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
0
1.1
92
allergic disease
0
1.1
80.4
eosinophil count
3
76.4
eosinophil percentage of leukocytes
1
60.5
Eczema
0
1.1
57.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
negative regulator of reactive oxygen species
VGNC:12100
104005928
Macaque
negative regulator of reactive oxygen species
710573
Mouse
MGI:2445095
224109
Rat
RGD:1310771
303875
Horse
negative regulator of reactive oxygen species
VGNC:52415
100069731
Species
Name
OMA
EggNOG
Inparanoid
Chimp
negative regulator of reactive oxygen species
Macaque
negative regulator of reactive oxygen species
Mouse
Rat
Horse
negative regulator of reactive oxygen species
Publication Statistics
PubMed Score 15.99
PubMed score by year
PubTator Score 5.12
PubTator score by year
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Related Publications
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PMID
Year
Title