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Tbio
NRP2
Neuropilin-2

Protein Summary
Description
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells. This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272849
  • ENSP00000272849
  • ENSG00000118257
  • ENST00000357118
  • ENSP00000349632
  • ENST00000357785
  • ENSP00000350432
  • ENST00000360409
  • ENSP00000353582
  • ENST00000412873
  • ENSP00000407626
  • ENST00000417189
  • ENSP00000387519

Symbol
  • VEGF165R2
  • NP2
  • NPN2
  • PRO2714
  • VEGF165R2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
PubMedID
0.96
protein domain
0.92
molecular function
0.91
microRNA
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.91   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 414   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.91   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
UPK2
Tbio
Novelty:  0.01066132
p_int:  0.999899229
p_ni:  0.000100771
Data Source:  BioPlex
COL20A1
Tdark
Novelty:  0.39788946
p_int:  0.988263745
p_ni:  0.011736252
p_wrong:  3e-9
Data Source:  BioPlex
ST8SIA3
Tbio
Family:  Enzyme
Novelty:  0.05984127
p_int:  0.98429353
p_ni:  0.01570647
Score:  0.219
Data Source:  BioPlex,STRINGDB
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.973422932
p_ni:  0.025363597
p_wrong:  0.00121347
Data Source:  BioPlex
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.968098837
p_ni:  0.031901163
Data Source:  BioPlex
NXPH2
Tdark
Novelty:  0.65790631
p_int:  0.945280178
p_ni:  0.052367715
p_wrong:  0.002352108
Data Source:  BioPlex
BRINP3
Tbio
Novelty:  0.07870037
p_int:  0.939732921
p_ni:  0.057898424
p_wrong:  0.002368655
Data Source:  BioPlex
ATP1B3
Tclin
Family:  Transporter
Novelty:  0.06773518
p_int:  0.938323277
p_ni:  0.058795743
p_wrong:  0.00288098
Data Source:  BioPlex
ST8SIA4
Tbio
Family:  Enzyme
Novelty:  0.00338436
p_int:  0.93756809
p_ni:  0.059284137
p_wrong:  0.003147774
Score:  0.498
Data Source:  BioPlex,STRINGDB
TSPAN11
Tdark
Novelty:  0.37247094
p_int:  0.936551964
p_ni:  0.063445861
p_wrong:  0.000002175
Score:  0.2
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (131)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
L1CAM interactions
Reactome
Neurophilin interactions with VEGF and VEGFR
Reactome
NrCAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
L1CAM interactions
Neurophilin interactions with VEGF and VEGFR
NrCAM interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
BHF-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
46.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuropilin 2
VGNC:2729
460111
Macaque
neuropilin 2
574301
Mouse
MGI:1100492
18187
Rat
RGD:621442
81527
Dog
neuropilin 2
VGNC:43975
488487
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuropilin 2
Macaque
neuropilin 2
Mouse
Rat
Dog
neuropilin 2
Publication Statistics
PubMed Score 151.91
PubMed score by year
PubTator Score 223.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title