Protein Summary
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells. This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
- ENST00000272849
- ENSP00000272849
- ENSG00000118257
- ENST00000357118
- ENSP00000349632
- ENST00000357785
- ENSP00000350432
- ENST00000360409
- ENSP00000353582
- ENST00000412873
- ENSP00000407626
- ENST00000417189
- ENSP00000387519
- VEGF165R2
- NP2
- NPN2
- PRO2714
- VEGF165R2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.98 | ||
PubMedID | 0.96 | ||
protein domain | 0.92 | ||
molecular function | 0.91 | ||
microRNA | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 151.91 (req: < 5)
Gene RIFs: 78 (req: <= 3)
Antibodies: 414 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 151.91 (req: >= 5)
Gene RIFs: 78 (req: > 3)
Antibodies: 414 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 34
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (89)
COL20A1
Novelty: 0.39788946
p_int: 0.988263745
p_ni: 0.011736252
p_wrong: 3e-9
Data Source: BioPlex
ST8SIA3
Family: Enzyme
Novelty: 0.05984127
p_int: 0.98429353
p_ni: 0.01570647
Score: 0.219
Data Source: BioPlex,STRINGDB
CSTL1
Novelty: 0.13370814
p_int: 0.973422932
p_ni: 0.025363597
p_wrong: 0.00121347
Data Source: BioPlex
NXPH2
Novelty: 0.65790631
p_int: 0.945280178
p_ni: 0.052367715
p_wrong: 0.002352108
Data Source: BioPlex
BRINP3
Novelty: 0.07870037
p_int: 0.939732921
p_ni: 0.057898424
p_wrong: 0.002368655
Data Source: BioPlex
ATP1B3
Family: Transporter
Novelty: 0.06773518
p_int: 0.938323277
p_ni: 0.058795743
p_wrong: 0.00288098
Data Source: BioPlex
ST8SIA4
Family: Enzyme
Novelty: 0.00338436
p_int: 0.93756809
p_ni: 0.059284137
p_wrong: 0.003147774
Score: 0.498
Data Source: BioPlex,STRINGDB
TSPAN11
Novelty: 0.37247094
p_int: 0.936551964
p_ni: 0.063445861
p_wrong: 0.000002175
Score: 0.2
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (131)
Reactome (8)
PathwayCommons (2)
WikiPathways (121)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | L1CAM interactions | ||||
Reactome | Neurophilin interactions with VEGF and VEGFR | ||||
Reactome | NrCAM interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
L1CAM interactions | ||||
Neurophilin interactions with VEGF and VEGFR | ||||
NrCAM interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (42)
Functions (8)
Components (8)
Processes (26)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
balding measurement | 1 | 1 | 1 | 46.1 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
balding measurement | 1 | 46.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | neuropilin 2 | VGNC:2729 | 460111 | |||||
Macaque | neuropilin 2 | 574301 | ||||||
Mouse | MGI:1100492 | 18187 | ||||||
Rat | RGD:621442 | 81527 | ||||||
Dog | neuropilin 2 | VGNC:43975 | 488487 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | neuropilin 2 | |||||
Macaque | neuropilin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | neuropilin 2 | |||||
Publication Statistics
PubMed Score 151.91
PubMed score by year
PubTator Score 223.40
PubTator score by year
Related Publications
Text Mined References (104)
GeneRif Annotations (78)
Items per page:
0 of 0
PMID | Year | Title |
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