Tbio NRP2 Neuropilin-2

Protein Summary

Description

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells. This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60462
• A0A024R3W6
• A0A024R412
• E9PF66
• O14820
• O14821
• Q53TQ4
• Q53TS3
• Q7LBX6
• Q7LBX7
• Q9H2D4
• Q9H2D5
• Q9H2E2
• Q9H2E3
• Q9H2E4
• X5D2Q8

Gene Name

• NRP2

Ensembl ID

• ENST00000272849
• ENSP00000272849
• ENSG00000118257
• ENST00000357118
• ENSP00000349632
• ENST00000357785
• ENSP00000350432
• ENST00000360409
• ENSP00000353582
• ENST00000412873
• ENSP00000407626
• ENST00000417189
• ENSP00000387519

Symbol

• VEGF165R2
• NP2
• NPN2
• PRO2714
• VEGF165R2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
PubMedID	0.96
protein domain	0.92
molecular function	0.91
microRNA	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.05   (req: < 5)

Gene RIFs: 78   (req: <= 3)

Antibodies: 414   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.05   (req: >= 5)

Gene RIFs: 78   (req: > 3)

Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0