Tbio NRP2 Neuropilin-2

Protein Summary

Description

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells. This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60462
• A0A024R3W6
• A0A024R412
• E9PF66
• O14820
• O14821
• Q53TQ4
• Q53TS3
• Q7LBX6
• Q7LBX7
• Q9H2D4
• Q9H2D5
• Q9H2E2
• Q9H2E3
• Q9H2E4
• X5D2Q8

Gene Name

• NRP2

Ensembl ID

• ENST00000272849
• ENSP00000272849
• ENSG00000118257
• ENST00000357118
• ENSP00000349632
• ENST00000357785
• ENSP00000350432
• ENST00000360409
• ENSP00000353582
• ENST00000412873
• ENSP00000407626
• ENST00000417189
• ENSP00000387519

Symbol

• VEGF165R2
• NP2
• NPN2
• PRO2714
• VEGF165R2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
PubMedID	0.96
protein domain	0.92
molecular function	0.91
microRNA	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.91   (req: < 5)

Gene RIFs: 78   (req: <= 3)

Antibodies: 414   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.91   (req: >= 5)

Gene RIFs: 78   (req: > 3)

Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (89)

Explore Interacting Targets

1 – 10 of 89

• See Interactions on String-DB

UPK2

Tbio

Novelty:  0.01066132

p_int:  0.999899229

p_ni:  0.000100771

Data Source:  BioPlex

COL20A1

Tdark

Novelty:  0.39788946

p_int:  0.988263745

p_ni:  0.011736252

p_wrong:  3e-9

Data Source:  BioPlex

ST8SIA3

Tbio

Family:  Enzyme

Novelty:  0.05984127

p_int:  0.98429353

p_ni:  0.01570647

Score:  0.219

Data Source:  BioPlex,STRINGDB

CSTL1

Tbio

Novelty:  0.13370814

p_int:  0.973422932

p_ni:  0.025363597

p_wrong:  0.00121347

Data Source:  BioPlex

DEFA5

Tbio

Novelty:  0.00863727

p_int:  0.968098837

p_ni:  0.031901163

Data Source:  BioPlex

NXPH2

Tdark

Novelty:  0.65790631

p_int:  0.945280178

p_ni:  0.052367715

p_wrong:  0.002352108

Data Source:  BioPlex

BRINP3

Tbio

Novelty:  0.07870037

p_int:  0.939732921

p_ni:  0.057898424

p_wrong:  0.002368655

Data Source:  BioPlex

ATP1B3

Tclin

Family:  Transporter

Novelty:  0.06773518

p_int:  0.938323277

p_ni:  0.058795743

p_wrong:  0.00288098

Data Source:  BioPlex

ST8SIA4

Tbio

Family:  Enzyme

Novelty:  0.00338436

p_int:  0.93756809

p_ni:  0.059284137

p_wrong:  0.003147774

Score:  0.498

Data Source:  BioPlex,STRINGDB

TSPAN11

Tdark

Novelty:  0.37247094

p_int:  0.936551964

p_ni:  0.063445861

p_wrong:  0.000002175

Score:  0.2

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (131)

Reactome (8)

PathwayCommons (2)

WikiPathways (121)

Axon guidance (R-HSA-422475)

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Find Similar Targets

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5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	L1CAM interactions	100 targets	R-HSA-373760
Reactome	Neurophilin interactions with VEGF and VEGFR	4 targets	R-HSA-194306
Reactome	NrCAM interactions	7 targets	R-HSA-447038

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
L1CAM interactions	100 targets	R-HSA-373760
Neurophilin interactions with VEGF and VEGFR	4 targets	R-HSA-194306
NrCAM interactions	7 targets	R-HSA-447038

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (42)

Functions (8)

Components (8)

Processes (26)

Find Similar Targets

Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
growth factor binding	Traceable Author Statement (TAS)	BHF-UCL
signaling receptor activity	Traceable Author Statement (TAS)	ProtInc
vascular endothelial growth factor-activated receptor activity	Traceable Author Statement (TAS)	ProtInc
cytokine binding	Non-traceable Author Statement (NAS)	BHF-UCL
semaphorin receptor activity	Non-traceable Author Statement (NAS)	UniProtKB
heparin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	1	1	1		46.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	1		46.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Calcium
Complete proteome
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Heparin-binding
Host-virus interaction

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
craniofacial phenotype
growth/size/body region phenotype
immune system phenotype
mortality/aging
muscle phenotype
nervous system phenotype
reproductive system phenotype
respiratory system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	neuropilin 2	VGNC:2729	460111
Macaque	neuropilin 2		574301
Mouse	neuropilin 2	MGI:1100492	18187
Rat	neuropilin 2	RGD:621442	81527
Dog	neuropilin 2	VGNC:43975	488487

Species	Name	OMA	EggNOG	Inparanoid
Chimp	neuropilin 2
Macaque	neuropilin 2
Mouse	neuropilin 2
Rat	neuropilin 2
Dog	neuropilin 2

Publication Statistics

PubMed Score 151.91

PubMed score by year

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PubTator Score 223.40

PubTator score by year

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Related Publications

Text Mined References (104)

GeneRif Annotations (78)

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10

0 of 0

PMID	Year	Title