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Tdark
NRIP2
Nuclear receptor-interacting protein 2

Protein Summary
Description
Down-regulates transcriptional activation by nuclear receptors such as NR1F2.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337508
  • ENSP00000337501
  • ENSG00000053702
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.61
tissue
0.6
cell line
0.55
biological process
0.53
microRNA
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.39   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.39   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
SF3A2
Tbio
Novelty:  0.03658692
Score:  0.734
Data Source:  STRINGDB
DYRK4
Tchem
Family:  Kinase
Novelty:  0.20045887
Score:  0.732
Data Source:  STRINGDB
SUSD5
Tdark
Novelty:  1.0992718
Score:  0.697
Data Source:  STRINGDB
RORB
Tchem
Family:  NR
Novelty:  0.0097843
Score:  0.676
Data Source:  STRINGDB
HERPUD2
Tdark
Novelty:  0.25680095
Score:  0.582
Data Source:  STRINGDB
TSPAN11
Tdark
Novelty:  0.37247094
Score:  0.569
Data Source:  STRINGDB
FKBP4
Tchem
Family:  Enzyme
Novelty:  0.0023525
Score:  0.559
Data Source:  STRINGDB
XIRP1
Tbio
Novelty:  0.0599323
Score:  0.558
Data Source:  STRINGDB
TSPAN9
Tbio
Novelty:  0.17982192
Score:  0.555
Data Source:  STRINGDB
PPP1R12C
Tdark
Family:  Enzyme
Novelty:  0.00465397
Score:  0.554
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
7
2
7
96.1
sex hormone-binding globulin measurement
4
1
4
76.1
estradiol measurement
1
1
1
70
mean corpuscular volume
1
1
1
68.8
vital capacity
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
7
96.1
sex hormone-binding globulin measurement
4
76.1
estradiol measurement
1
70
mean corpuscular volume
1
68.8
vital capacity
1
62.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor interacting protein 2
VGNC:5508
466918
Macaque
nuclear receptor interacting protein 2
721734
Mouse
MGI:1891884
60345
Rat
RGD:1589959
689619
Dog
nuclear receptor interacting protein 2
VGNC:43970
486744
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor interacting protein 2
Macaque
nuclear receptor interacting protein 2
Mouse
Rat
Dog
nuclear receptor interacting protein 2
Publication Statistics
PubMed Score 1.39
PubMed score by year
PubTator Score 0.25
PubTator score by year
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Related Publications
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PMID
Year
Title