Tbio NRGN Neurogranin

Protein Summary

Description

Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92686
• Ng

Gene Name

• NRGN

Ensembl ID

• ENST00000284292
• ENSP00000284292
• ENSG00000154146
• ENST00000412681
• ENSP00000399591

Symbol

• RC3
• hng

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.78
PubMedID	0.77
histone modification site profile	0.75
transcription factor binding site profile	0.62
transcription factor	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.46   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.46   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

TRIM62

Tbio

Family:  Enzyme

Novelty:  0.12565021

p_int:  0.999999968

p_ni:  1.9e-8

p_wrong:  1.3e-8

Score:  0.369

Data Source:  BioPlex,STRINGDB

EFCAB7

Tdark

Novelty:  0.36952617

p_int:  0.999999255

p_ni:  1.93e-7

p_wrong:  5.52e-7

Score:  0.218

Data Source:  BioPlex,STRINGDB

KLHL20

Tbio

Novelty:  0.12205871

p_int:  0.999209417

p_ni:  0.000757297

p_wrong:  0.000033287

Data Source:  BioPlex

RWDD2B

Tdark

Novelty:  0.42452529

p_int:  0.998822309

p_ni:  0.001139677

p_wrong:  0.000038014

Score:  0.239

Data Source:  BioPlex,STRINGDB

NUDT6

Tbio

Novelty:  0.03648851

p_int:  0.998822309

p_ni:  0.001139677

p_wrong:  0.000038014

Score:  0.239

Data Source:  BioPlex,STRINGDB

MED9

Tbio

Family:  Enzyme

Novelty:  0.19660296

p_int:  0.997524797

p_ni:  0.002415994

p_wrong:  0.000059208

Score:  0.188

Data Source:  BioPlex,STRINGDB

CALM1

Tclin

Novelty:  0.00308267

Score:  0.805

Data Source:  Reactome,STRINGDB

OPALIN

Tdark

Novelty:  0.08221612

Score:  0.766

Data Source:  STRINGDB

ZNF804A

Tbio

Novelty:  0.00751648

Score:  0.737

Data Source:  STRINGDB

NGRN

Tbio

Novelty:  0.11162143

Score:  0.708

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (6)

Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Reactome	Long-term potentiation	23 targets	R-HSA-9620244
Reactome	Neuronal System	398 targets	R-HSA-112316
Reactome	Neurotransmitter receptors and postsynaptic signal transmission	186 targets	R-HSA-112314
Reactome	Post NMDA receptor activation events	62 targets	R-HSA-438064

Name	Explore in Pharos	Explore in Source
Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Long-term potentiation	23 targets	R-HSA-9620244
Neuronal System	398 targets	R-HSA-112316
Neurotransmitter receptors and postsynaptic signal transmission	186 targets	R-HSA-112314
Post NMDA receptor activation events	62 targets	R-HSA-438064

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (3)

Components (10)

Processes (6)

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1 – 3 of 3

GO Term	Evidence	Assigned by
calmodulin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphatidic acid binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphatidylinositol-3,4,5-trisphosphate binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (6)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum metabolite measurement	EFO_0005653	1	1	1		60.2
schizophrenia	EFO_0000692	8	1	2	1.1	57.3
autism spectrum disorder	EFO_0003756	1	1	0	1.1	56.8
self reported educational attainment	EFO_0004784	1	1	1		40.7
intelligence	EFO_0004337	1	1	1		40.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum metabolite measurement	EFO_0005653	1		60.2
schizophrenia	EFO_0000692	2	1.1	57.3
autism spectrum disorder	EFO_0003756	0	1.1	56.8
self reported educational attainment	EFO_0004784	1		40.7
intelligence	EFO_0004337	1		40.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Calmodulin-binding
Citrullination
Complete proteome
Methylation
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
autism spectrum disorder
intelligence
schizophrenia
self reported educational attainment
serum metabolite measurement
smoking status measurement

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	neurogranin	VGNC:3088	451638
Macaque	neurogranin		716063
Mouse	neurogranin	MGI:1927184	64011
Rat	neurogranin	RGD:61833	64356
Horse	neurogranin	VGNC:20885	100072257

Species	Name	OMA	EggNOG	Inparanoid
Chimp	neurogranin
Macaque	neurogranin
Mouse	neurogranin
Rat	neurogranin
Horse	neurogranin

Publication Statistics

PubMed Score 300.46

PubMed score by year

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PubTator Score 162.31

PubTator score by year

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Related Publications

Text Mined References (45)

GeneRif Annotations (31)

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PMID	Year	Title