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Tbio
NRGN
Neurogranin

Protein Summary
Description
Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284292
  • ENSP00000284292
  • ENSG00000154146
  • ENST00000412681
  • ENSP00000399591

Symbol
  • RC3
  • hng
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.78
PubMedID
0.77
histone modification site profile
0.75
transcription factor binding site profile
0.62
transcription factor
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.46   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.46   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
TRIM62
Tbio
Family:  Enzyme
Novelty:  0.12565021
p_int:  0.999999968
p_ni:  1.9e-8
p_wrong:  1.3e-8
Score:  0.369
Data Source:  BioPlex,STRINGDB
EFCAB7
Tdark
Novelty:  0.36952617
p_int:  0.999999255
p_ni:  1.93e-7
p_wrong:  5.52e-7
Score:  0.218
Data Source:  BioPlex,STRINGDB
KLHL20
Tbio
Novelty:  0.12205871
p_int:  0.999209417
p_ni:  0.000757297
p_wrong:  0.000033287
Data Source:  BioPlex
RWDD2B
Tdark
Novelty:  0.42452529
p_int:  0.998822309
p_ni:  0.001139677
p_wrong:  0.000038014
Score:  0.239
Data Source:  BioPlex,STRINGDB
NUDT6
Tbio
Novelty:  0.03648851
p_int:  0.998822309
p_ni:  0.001139677
p_wrong:  0.000038014
Score:  0.239
Data Source:  BioPlex,STRINGDB
MED9
Tbio
Family:  Enzyme
Novelty:  0.19660296
p_int:  0.997524797
p_ni:  0.002415994
p_wrong:  0.000059208
Score:  0.188
Data Source:  BioPlex,STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.805
Data Source:  Reactome,STRINGDB
OPALIN
Tdark
Novelty:  0.08221612
Score:  0.766
Data Source:  STRINGDB
ZNF804A
Tbio
Novelty:  0.00751648
Score:  0.737
Data Source:  STRINGDB
NGRN
Tbio
Novelty:  0.11162143
Score:  0.708
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Long-term potentiation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Post NMDA receptor activation events
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Long-term potentiation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Post NMDA receptor activation events
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
1
1
60.2
8
1
2
1.1
57.3
1
1
0
1.1
56.8
self reported educational attainment
1
1
1
40.7
intelligence
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
60.2
2
1.1
57.3
0
1.1
56.8
self reported educational attainment
1
40.7
intelligence
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurogranin
VGNC:3088
451638
Macaque
neurogranin
716063
Mouse
MGI:1927184
64011
Rat
RGD:61833
64356
Horse
neurogranin
VGNC:20885
100072257
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurogranin
Macaque
neurogranin
Mouse
Rat
Horse
neurogranin
Publication Statistics
PubMed Score 300.46
PubMed score by year
PubTator Score 162.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title