Protein Summary
Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]
- ENST00000284292
- ENSP00000284292
- ENSG00000154146
- ENST00000412681
- ENSP00000399591
- RC3
- hng
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
small molecule perturbation | 0.78 | ||
PubMedID | 0.77 | ||
histone modification site profile | 0.75 | ||
transcription factor binding site profile | 0.62 | ||
transcription factor | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 300.46 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 300.46 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (83)
TRIM62
Family: Enzyme
Novelty: 0.12565021
p_int: 0.999999968
p_ni: 1.9e-8
p_wrong: 1.3e-8
Score: 0.369
Data Source: BioPlex,STRINGDB
EFCAB7
Novelty: 0.36952617
p_int: 0.999999255
p_ni: 1.93e-7
p_wrong: 5.52e-7
Score: 0.218
Data Source: BioPlex,STRINGDB
KLHL20
Novelty: 0.12205871
p_int: 0.999209417
p_ni: 0.000757297
p_wrong: 0.000033287
Data Source: BioPlex
RWDD2B
Novelty: 0.42452529
p_int: 0.998822309
p_ni: 0.001139677
p_wrong: 0.000038014
Score: 0.239
Data Source: BioPlex,STRINGDB
NUDT6
Novelty: 0.03648851
p_int: 0.998822309
p_ni: 0.001139677
p_wrong: 0.000038014
Score: 0.239
Data Source: BioPlex,STRINGDB
MED9
Family: Enzyme
Novelty: 0.19660296
p_int: 0.997524797
p_ni: 0.002415994
p_wrong: 0.000059208
Score: 0.188
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of NMDA receptors and postsynaptic events | ||||
Reactome | Long-term potentiation | ||||
Reactome | Neuronal System | ||||
Reactome | Neurotransmitter receptors and postsynaptic signal transmission | ||||
Reactome | Post NMDA receptor activation events | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of NMDA receptors and postsynaptic events | ||||
Long-term potentiation | ||||
Neuronal System | ||||
Neurotransmitter receptors and postsynaptic signal transmission | ||||
Post NMDA receptor activation events | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (3)
Components (10)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
serum metabolite measurement | 1 | 1 | 1 | 60.2 | |||||
8 | 1 | 2 | 1.1 | 57.3 | |||||
1 | 1 | 0 | 1.1 | 56.8 | |||||
self reported educational attainment | 1 | 1 | 1 | 40.7 | |||||
intelligence | 1 | 1 | 1 | 40.7 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
serum metabolite measurement | 1 | 60.2 | |||||
2 | 1.1 | 57.3 | |||||
0 | 1.1 | 56.8 | |||||
self reported educational attainment | 1 | 40.7 | |||||
intelligence | 1 | 40.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | neurogranin | VGNC:3088 | 451638 | |||||
Macaque | neurogranin | 716063 | ||||||
Mouse | MGI:1927184 | 64011 | ||||||
Rat | RGD:61833 | 64356 | ||||||
Horse | neurogranin | VGNC:20885 | 100072257 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | neurogranin | |||||
Macaque | neurogranin | |||||
Mouse | ||||||
Rat | ||||||
Horse | neurogranin | |||||
Publication Statistics
PubMed Score 300.46
PubMed score by year
PubTator Score 162.31
PubTator score by year
Related Publications
Text Mined References (45)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
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