Tbio NRG3 Pro-neuregulin-3, membrane-bound isoform

Protein Summary

Description

Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• P56975
• A4D7U1
• Q0PEH2
• Q5VYH3
• Pro-NRG3

Gene Name

• NRG3

Ensembl ID

• ENST00000372141
• ENSP00000361214
• ENSG00000185737
• ENST00000372142
• ENSP00000361215
• ENST00000404547
• ENSP00000384796

Symbol

• HRG3
• pro-NRG3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
gene perturbation	0.86
disease	0.73
transcription factor	0.73
cell line	0.63

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Pro-neuregulin-3, Membrane-bound Isoform

DTO Classes

Protein / Signaling / Growth Factor / Pro-neuregulin-3, Membrane-bound Isoform

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.1   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.1   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0