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Tbio
NRBP1
Nuclear receptor-binding protein

Protein Summary
Description
May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233557
  • ENSP00000233557
  • ENSG00000115216
  • ENST00000379852
  • ENSP00000369181

Symbol
  • BCON3
  • NRBP
  • MADM
  • NRBP
  • BCON3
  • MUDPNP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
drug perturbation
0.87
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.69
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.96   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.96   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0