Tchem NR5A2 Nuclear receptor subfamily 5 group A member 2

Protein Summary

Description

Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 subfamily of orphan nuclear receptors. The encoded protein is involved in the expression of genes for hepatitis B virus and cholesterol biosynthesis, and may be an important regulator of embryonic development. [provided by RefSeq, Jun 2016]

Uniprot Accession IDs

• O00482
• B4E2P3
• O95642
• Q147U3

Gene Name

• NR5A2

Ensembl ID

• ENST00000236914
• ENSP00000236914
• ENSG00000116833
• ENST00000367362
• ENSP00000356331
• ENST00000544748
• ENSP00000439116

Symbol

• B1F
• CPF
• FTF
• B1F
• CPF
• FTF
• B1F2
• LRH1
• LRH-1
• FTZ-F1
• hB1F-2
• FTZ-F1beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
trait	0.93
protein domain	0.85
transcription factor	0.78
disease	0.76

Protein Classes

PANTHER Classes

Protein / ... / C4 Zinc Finger Nuclear Receptor / Nuclear Receptor Subfamily 5 Group A Member 2

DTO Classes

Protein / Nuclear Receptor / Fushi Tarazu F1-like Receptors / Nuclear Receptor Subfamily 5 Group A Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.3   (req: < 5)

Gene RIFs: 131   (req: <= 3)

Antibodies: 447   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.3   (req: >= 5)

Gene RIFs: 131   (req: > 3)

Antibodies: 447   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0