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Tclin
NR3C2
Mineralocorticoid receptor

Protein Summary
Description
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342437
  • ENSP00000343907
  • ENSG00000151623
  • ENST00000344721
  • ENSP00000341390
  • ENST00000358102
  • ENSP00000350815
  • ENST00000511528
  • ENSP00000421481
  • ENST00000512865
  • ENSP00000423510
  • ENST00000625323
  • ENSP00000486719

Symbol
  • MCR
  • MLR
  • MR
  • MCR
  • MLR
  • NR3C2VIT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
virus perturbation
0.9
microRNA
0.83
disease
0.82
molecular function
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4599.91   (req: < 5)
Gene RIFs: 172   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4599.91   (req: >= 5)
Gene RIFs: 172   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 281
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 16
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (16)
progesterone
Rendered image for progesterone
nimodipine
Rendered image for nimodipine
prednisolone
Rendered image for prednisolone
desoxycortone
Rendered image for desoxycortone
hydrocortisone
Rendered image for hydrocortisone
budesonide
Rendered image for budesonide
dexamethasone
Rendered image for dexamethasone
fluticasone propionate
Rendered image for fluticasone propionate
spironolactone
Rendered image for spironolactone
drospirenone
Rendered image for drospirenone
Protein-Protein Interactions (142)
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
p_int:  0.964682861
p_ni:  2e-9
p_wrong:  0.035317138
Score:  0.231
Data Source:  BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.967
Data Source:  STRINGDB
FKBP4
Tchem
Family:  Enzyme
Novelty:  0.0023525
Score:  0.965
Data Source:  STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
Score:  0.96
Data Source:  STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.95
Data Source:  Reactome,STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.947
Data Source:  Reactome,STRINGDB
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.945
Data Source:  STRINGDB
NR3C1
Tclin
Family:  NR
Novelty:  0.00029396
Score:  0.943
Data Source:  STRINGDB
PIAS1
Tbio
Family:  TF
Novelty:  0.00987743
Score:  0.941
Data Source:  STRINGDB
HSP90AB1
Tchem
Novelty:  0.00907961
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Gene expression (Transcription)
Generic Transcription Pathway
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
11.1
92.3
sex hormone-binding globulin measurement
6
2
6
91.2
central corneal thickness
2
2
0
3.5
81.6
hemoglobin measurement
2
2
2
80.6
hematocrit
2
2
2
78.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
11.1
92.3
sex hormone-binding globulin measurement
6
91.2
central corneal thickness
0
3.5
81.6
hemoglobin measurement
2
80.6
hematocrit
2
78.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 3 group C member 2
VGNC:2971
461533
Macaque
nuclear receptor subfamily 3 group C member 2
704789
Mouse
MGI:99459
110784
Rat
RGD:3094
25672
Dog
nuclear receptor subfamily 3 group C member 2
VGNC:43953
475461
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 3 group C member 2
Macaque
nuclear receptor subfamily 3 group C member 2
Mouse
Rat
Dog
nuclear receptor subfamily 3 group C member 2
Publication Statistics
PubMed Score 4599.91
PubMed score by year
PubTator Score 1246.37
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title