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Tclin
NR3C1
Glucocorticoid receptor

Protein Summary
Description
Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). Isoform Alpha: Has transcriptional activation and repression activity (PubMed:15866175, PubMed:19248771, PubMed:20484466, PubMed:23820903, PubMed:11435610, PubM ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231509
  • ENSP00000231509
  • ENSG00000113580
  • ENST00000343796
  • ENSP00000343205
  • ENST00000394464
  • ENSP00000377977
  • ENST00000394466
  • ENSP00000377979
  • ENST00000415690
  • ENSP00000387672
  • ENST00000424646
  • ENSP00000405282
  • ENST00000503201
  • ENSP00000427672
  • ENST00000504572
  • ENSP00000422518

Symbol
  • GRL
  • GR
  • GCR
  • GRL
  • GCCR
  • GCRST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
hub protein
1
molecular function
1
transcription factor perturbation
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3248.35   (req: < 5)
Gene RIFs: 668   (req: <= 3)
Antibodies: 1148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3248.35   (req: >= 5)
Gene RIFs: 668   (req: > 3)
Antibodies: 1148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1750
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 71