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Tclin
NR3C1
Glucocorticoid receptor

Protein Summary
Description
Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). Isoform Alpha: Has transcriptional activation and repression activity (PubMed:15866175, PubMed:19248771, PubMed:20484466, PubMed:23820903, PubMed:11435610, PubM ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231509
  • ENSP00000231509
  • ENSG00000113580
  • ENST00000343796
  • ENSP00000343205
  • ENST00000394464
  • ENSP00000377977
  • ENST00000394466
  • ENSP00000377979
  • ENST00000415690
  • ENSP00000387672
  • ENST00000424646
  • ENSP00000405282
  • ENST00000503201
  • ENSP00000427672
  • ENST00000504572
  • ENSP00000422518

Symbol
  • GRL
  • GR
  • GCR
  • GRL
  • GCCR
  • GCRST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
hub protein
1
molecular function
1
transcription factor perturbation
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2693.57   (req: < 5)
Gene RIFs: 668   (req: <= 3)
Antibodies: 1148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2693.57   (req: >= 5)
Gene RIFs: 668   (req: > 3)
Antibodies: 1148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1733
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 71
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (71)
progesterone
Rendered image for progesterone
podophyllotoxin
Rendered image for podophyllotoxin
medroxyprogesterone
Rendered image for medroxyprogesterone
prednisolone
Rendered image for prednisolone
desoxycortone
Rendered image for desoxycortone
hydrocortisone
Rendered image for hydrocortisone
mifepristone
Rendered image for mifepristone
prednisolone tebutate
Rendered image for prednisolone tebutate
budesonide
Rendered image for budesonide
cortisone acetate
Rendered image for cortisone acetate
Protein-Protein Interactions (372)
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.99996607
p_ni:  0.00003393
Data Source:  BioPlex
CAMK2B
Tchem
Family:  Kinase
Novelty:  0.00793595
p_int:  0.999567735
p_ni:  0.000432265
Data Source:  BioPlex
CAMK2G
Tchem
Family:  Kinase
Novelty:  0.04642387
p_int:  0.999413412
p_ni:  0.000586588
Data Source:  BioPlex
CAMK2D
Tchem
Family:  Kinase
Novelty:  0.02326864
p_int:  0.999144432
p_ni:  0.000855568
Data Source:  BioPlex
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.99214719
p_ni:  0.00000261
p_wrong:  0.007850201
Score:  0.238
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.8910199
p_ni:  0.1089801
Score:  0.944
Data Source:  BioPlex,STRINGDB
NCOA2
Tbio
Novelty:  0.00510052
Score:  0.998
Data Source:  STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
Score:  0.991
Data Source:  STRINGDB
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
Score:  0.988
Data Source:  STRINGDB
NCOR1
Tchem
Family:  TF
Novelty:  0.0021926
Score:  0.986
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (42)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Circadian Clock
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Circadian Clock
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (40)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
4
91.1
2
2
0
1.1
70.2
lymphocyte percentage of leukocytes
1
1
1
56.4
hemoglobin measurement
2
2
2
56.3
BMI-adjusted hip circumference
1
3
3
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
91.1
0
1.1
70.2
lymphocyte percentage of leukocytes
1
56.4
hemoglobin measurement
2
56.3
BMI-adjusted hip circumference
3
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 3 group C member 1
VGNC:4104
471681
Macaque
nuclear receptor subfamily 3 group C member 1
706198
Mouse
MGI:95824
14815
Dog
nuclear receptor subfamily 3 group C member 1
VGNC:43952
478047
Horse
nuclear receptor subfamily 3 group C member 1
VGNC:20869
100061217
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 3 group C member 1
Macaque
nuclear receptor subfamily 3 group C member 1
Mouse
Dog
nuclear receptor subfamily 3 group C member 1
Horse
nuclear receptor subfamily 3 group C member 1
Publication Statistics
PubMed Score 2693.57
PubMed score by year
PubTator Score 3718.72
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title