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Tbio
NR2F6
Nuclear receptor subfamily 2 group F member 6

Protein Summary
Description
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and m ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291442
  • ENSP00000291442
  • ENSG00000160113

Symbol
  • EAR2
  • ERBAL2
  • EAR2
  • EAR-2
  • ERBAL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor perturbation
0.94
disease perturbation
0.9
protein domain
0.85
interacting protein
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.49   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.49   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
MPPED1
Tdark
Family:  Enzyme
Novelty:  0.58103321
p_int:  0.99999526
p_ni:  0.00000474
Score:  0.729
Data Source:  BioPlex,STRINGDB
MPPED2
Tbio
Family:  Enzyme
Novelty:  0.091909
p_int:  0.999991419
p_ni:  0.000008581
Score:  0.866
Data Source:  BioPlex,STRINGDB
NR2F2
Tchem
Family:  NR
Novelty:  0.00450561
p_int:  0.999940023
p_ni:  0.000057367
p_wrong:  0.000002611
Score:  0.705
Data Source:  BioPlex,STRINGDB
CADM4
Tbio
Novelty:  0.05034541
p_int:  0.993154573
p_ni:  0.006614573
p_wrong:  0.000230854
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.989107264
p_ni:  0.010886758
p_wrong:  0.000005978
Data Source:  BioPlex
RXRG
Tclin
Family:  NR
Novelty:  0.01646377
p_int:  0.933227549
p_ni:  0.004492189
p_wrong:  0.062280262
Score:  0.29
Data Source:  BioPlex,STRINGDB
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.899185616
p_ni:  0.002842608
p_wrong:  0.097971775
Data Source:  BioPlex
NECTIN2
Tbio
Novelty:  0.00910836
p_int:  0.820579509
p_ni:  0.179404843
p_wrong:  0.000015648
Data Source:  BioPlex
INPP5A
Tchem
Family:  Enzyme
Novelty:  0.03249263
p_int:  0.788904347
p_ni:  0.210962123
p_wrong:  0.000133531
Data Source:  BioPlex
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
p_int:  0.782323902
p_ni:  0.217676098
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
4
6
6
98.7
6
4
0
1.2
98.5
2
3
0
1.2
96.8
HbA1c measurement
4
7
7
96.5
testosterone measurement
5
3
5
94.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
6
98.7
0
1.2
98.5
0
1.2
96.8
HbA1c measurement
7
96.5
testosterone measurement
5
94.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 2 group F member 6
VGNC:3626
748739
Macaque
nuclear receptor subfamily 2 group F member 6
719699
Mouse
MGI:1352453
13864
Rat
RGD:621685
245980
Dog
nuclear receptor subfamily 2 group F member 6
VGNC:43951
609720
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 2 group F member 6
Macaque
nuclear receptor subfamily 2 group F member 6
Mouse
Rat
Dog
nuclear receptor subfamily 2 group F member 6
Publication Statistics
PubMed Score 65.49
PubMed score by year
PubTator Score 36.18
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title