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Tchem
NR2F2
COUP transcription factor 2

Protein Summary
Description
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394166
  • ENSP00000377721
  • ENSG00000185551
  • ENST00000394171
  • ENSP00000377726
  • ENST00000421109
  • ENSP00000401674
  • ENST00000453270
  • ENSP00000389853

Symbol
  • ARP1
  • TFCOUP2
  • ARP1
  • ARP-1
  • CHTD4
  • NF-E3
  • SVP40
  • COUPTF2
  • COUPTFB
  • TFCOUP2
  • COUPTFII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
molecular function
0.99
biological process
0.98
PubMedID
0.95
transcription factor
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.95   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.95   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0