NR2F1
COUP transcription factor 1
Protein Summary
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG. The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014]
- ENST00000327111
- ENSP00000325819
- ENSG00000175745
- ENST00000644230
- ENSP00000495420
- EAR3
- ERBAL3
- TFCOUP1
- EAR3
- BBOAS
- EAR-3
- SVP44
- BBSOAS
- ERBAL3
- COUPTF1
- TFCOUP1
- COUP-TFI
- TCFCOUP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.98 | ||
molecular function | 0.94 | ||
gene perturbation | 0.86 | ||
protein domain | 0.85 | ||
transcription factor binding site profile | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 183.75 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 254 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 183.75 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 254 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (106)
CD70
Novelty: 0.00420393
p_int: 0.967681698
p_ni: 0.032318302
Score: 0.177
Data Source: BioPlex,STRINGDB
MPPED1
Family: Enzyme
Novelty: 0.58103321
p_int: 0.957949316
p_ni: 0.042050684
Score: 0.239
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (27)
Reactome (4)
WikiPathways (23)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Nuclear Receptor transcription pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Nuclear Receptor transcription pathway | ||||
RNA Polymerase II Transcription | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (10)
Components (3)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence Model (ISM) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 4 | 5 | 92.4 | |||||
self reported educational attainment | 1 | 1 | 1 | 71.9 | |||||
soluble triggering receptor expressed on myeloid cells 2 measurement | 1 | 1 | 0 | 15744.7 | 53.3 | ||||
diet measurement | 2 | 2 | 2 | 50.5 | |||||
cognitive function measurement | 1 | 1 | 1 | 40.7 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 5 | 92.4 | |||||
self reported educational attainment | 1 | 71.9 | |||||
soluble triggering receptor expressed on myeloid cells 2 measurement | 0 | 15744.7 | 53.3 | ||||
diet measurement | 2 | 50.5 | |||||
cognitive function measurement | 1 | 40.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | nuclear receptor subfamily 2 group F member 1 | VGNC:4103 | 461753 | |||||
Macaque | nuclear receptor subfamily 2 group F member 1 | 700777 | ||||||
Mouse | MGI:1352451 | 13865 | ||||||
Rat | RGD:621682 | 81808 | ||||||
Cow | nuclear receptor subfamily 2 group F member 1 | VGNC:32240 | 327684 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | nuclear receptor subfamily 2 group F member 1 | |||||
Macaque | nuclear receptor subfamily 2 group F member 1 | |||||
Mouse | ||||||
Rat | ||||||
Cow | nuclear receptor subfamily 2 group F member 1 | |||||
Publication Statistics
PubMed Score 183.75
PubMed score by year
PubTator Score 125.73
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (43)
GeneRif Annotations (26)
Items per page:
0 of 0
PMID | Year | Title |
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