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Tchem
NR1I3
Nuclear receptor subfamily 1 group I member 3

Protein Summary
Description
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign comp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367979
  • ENSP00000356958
  • ENSG00000143257
  • ENST00000367980
  • ENSP00000356959
  • ENST00000367981
  • ENSP00000356960
  • ENST00000367982
  • ENSP00000356961
  • ENST00000367983
  • ENSP00000356962
  • ENST00000367984
  • ENSP00000356963
  • ENST00000367985
  • ENSP00000356965
  • ENST00000412844
  • ENSP00000399361
  • ENST00000428574
  • ENSP00000412672
  • ENST00000437437
  • ENSP00000407446
  • ENST00000442691
  • ENSP00000406493
  • ENST00000504010
  • ENSP00000424345
  • ENST00000505005
  • ENSP00000424934
  • ENST00000508740
  • ENSP00000423666
  • ENST00000511676
  • ENSP00000427175
  • ENST00000512372
  • ENSP00000425417

Symbol
  • CAR
  • CAR
  • CAR1
  • MB67
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
molecular function
0.97
protein domain
0.85
tissue sample
0.65
biological process
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 349.99   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 409   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 349.99   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2