You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NR1D2
Nuclear receptor subfamily 1 group D member 2

Protein Summary
Description
Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312521
  • ENSP00000310006
  • ENSG00000174738

Symbol
  • RVR
  • BD73
  • EAR-1R
  • REVERBB
  • REVERBbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
virus perturbation
0.85
disease perturbation
0.79
biological process
0.75
small molecule perturbation
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.33   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.33   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (45)
USP48
Tbio
Family:  Enzyme
Novelty:  0.10103618
p_int:  0.999335144
p_ni:  0.000595618
p_wrong:  0.000069238
Score:  0.19
Data Source:  BioPlex,STRINGDB
NR1D1
Tchem
Family:  NR
Novelty:  0.00250799
p_int:  0.978675871
p_wrong:  0.021324128
Score:  0.897
Data Source:  BioPlex,STRINGDB
SATB2
Tbio
Family:  TF
Novelty:  0.00405935
p_int:  0.768301332
p_ni:  0.005192884
p_wrong:  0.226505784
Score:  0.237
Data Source:  BioPlex,STRINGDB
ZNF703
Tbio
Novelty:  0.03956045
p_int:  0.751462482
p_ni:  0.24852319
p_wrong:  0.000014327
Score:  0.242
Data Source:  BioPlex,STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
Score:  0.905
Data Source:  STRINGDB
DBP
Tbio
Family:  TF
Novelty:  0.02264853
Score:  0.897
Data Source:  STRINGDB
CRY1
Tchem
Novelty:  0.00116593
Score:  0.878
Data Source:  STRINGDB
ARNTL
Tbio
Family:  TF
Novelty:  0.00102829
Score:  0.876
Data Source:  STRINGDB
PER3
Tbio
Novelty:  0.00350199
Score:  0.858
Data Source:  STRINGDB
CLOCK
Tbio
Family:  TF; Epigenetic
Novelty:  0.00159625
Score:  0.83
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (31)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
8
15
8
6.3
96.8
self reported educational attainment
4
3
3
5.7
87.6
vitamin D measurement
1
1
1
81.7
cognitive function measurement
3
2
3
76.1
mathematical ability
3
3
3
75.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
8
6.3
96.8
self reported educational attainment
3
5.7
87.6
vitamin D measurement
1
81.7
cognitive function measurement
3
76.1
mathematical ability
3
75.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 1 group D member 2
VGNC:7078
460230
Macaque
nuclear receptor subfamily 1 group D member 2
701624
Mouse
MGI:2449205
353187
Rat
RGD:628828
259241
Dog
nuclear receptor subfamily 1 group D member 2
VGNC:43941
485643
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 1 group D member 2
Macaque
nuclear receptor subfamily 1 group D member 2
Mouse
Rat
Dog
nuclear receptor subfamily 1 group D member 2
Publication Statistics
PubMed Score 87.33
PubMed score by year
PubTator Score 124.36
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title