Tchem NPY4R Neuropeptide Y receptor type 4

Protein Summary

Description

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

Uniprot Accession IDs

• P50391
• Q13456
• Q5ISU3
• Q5T2X9
• Q6FH06
• NPY4-R

Gene Name

• NPY4R

Ensembl ID

• ENST00000374312
• ENSP00000363431
• ENSG00000204174
• ENST00000395716
• ENSP00000379066
• ENST00000612632
• ENSP00000480883

Symbol

• PPYR1
• PP1
• NPY4R
• PPYR1
• NPY4-R
• CH17-360D5.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.97
ligand (chemical)	0.7
ligand (protein)	0.68
chemical	0.46
cell line	0.43

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Neuropeptide Y Receptor / Neuropeptide Y Receptor Type 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.12   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 222   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.12   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 106

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0