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Tchem
NPY1R
Neuropeptide Y receptor type 1

Protein Summary
Description
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid. This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296533
  • ENSP00000354652
  • ENSG00000164128

Symbol
  • NPYR
  • NPYY1
  • NPYR
  • NPY1-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
small molecule perturbation
0.81
ligand (chemical)
0.76
disease
0.72
ligand (protein)
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.33   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.33   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 325
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (288)
NPY
Tbio
Novelty:  0.00012637
Score:  0.997
Data Source:  Reactome,STRINGDB
PYY
Tbio
Novelty:  0.00060997
Score:  0.989
Data Source:  Reactome,STRINGDB
GAL
Tbio
Novelty:  0.0005132
Score:  0.972
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.954
Data Source:  STRINGDB
GALR2
Tchem
Family:  GPCR
Novelty:  0.00928558
Score:  0.954
Data Source:  STRINGDB
PPY
Tbio
Novelty:  0.00060933
Score:  0.951
Data Source:  Reactome,STRINGDB
SST
Tbio
Novelty:  0.00005944
Score:  0.946
Data Source:  STRINGDB
NPY5R
Tchem
Family:  GPCR
Novelty:  0.01747655
Score:  0.944
Data Source:  STRINGDB
PDYN
Tbio
Novelty:  0.00039564
Score:  0.94
Data Source:  STRINGDB
PNOC
Tbio
Novelty:  0.00132014
Score:  0.929
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
4
4
82.6
triglyceride measurement
1
1
0
6.4
44.2
self reported educational attainment
1
1
1
8.1
wellbeing measurement
2
1
2
8.1
daytime rest measurement
1
1
1
7.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
82.6
triglyceride measurement
0
6.4
44.2
self reported educational attainment
1
8.1
wellbeing measurement
2
8.1
daytime rest measurement
1
7.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuropeptide Y receptor Y1
VGNC:648
471331
Macaque
neuropeptide Y receptor Y1
574206
Mouse
MGI:104963
18166
Rat
RGD:3198
29358
Dog
neuropeptide Y receptor Y1
VGNC:43937
399518
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuropeptide Y receptor Y1
Macaque
neuropeptide Y receptor Y1
Mouse
Rat
Dog
neuropeptide Y receptor Y1
Publication Statistics
PubMed Score 138.33
PubMed score by year
PubTator Score 21.61
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title