Protein Summary
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
- ENST00000242152
- ENSP00000242152
- ENSG00000122585
- ENST00000405982
- ENSP00000385282
- ENST00000407573
- ENSP00000384364
- PYY4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.98 | ||
PubMedID | 0.86 | ||
disease | 0.82 | ||
disease perturbation | 0.79 | ||
chemical | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8728.7 (req: < 5)
Gene RIFs: 213 (req: <= 3)
Antibodies: 554 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8728.7 (req: >= 5)
Gene RIFs: 213 (req: > 3)
Antibodies: 554 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (431)
Nearest Tclin Targets (21)
Upstream (3)
Downstream (18)
1 – 3 of 3
Pathways (36)
Reactome (12)
KEGG (5)
PathwayCommons (6)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | FOXO-mediated transcription | ||||
Reactome | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
FOXO-mediated transcription | ||||
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (6)
Components (4)
Processes (20)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
comparative body size at age 10, self-reported | 1 | 1 | 1 | 13.5 | |||||
body mass index | 2 | 1 | 2 | 9.6 | |||||
body height | 1 | 1 | 1 | 1 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
comparative body size at age 10, self-reported | 1 | 13.5 | |||||
body mass index | 2 | 9.6 | |||||
body height | 1 | 1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | neuropeptide Y | VGNC:4448 | 744617 | |||||
Macaque | neuropeptide Y | 574114 | ||||||
Mouse | MGI:97374 | 109648 | ||||||
Rat | RGD:6487865 | 100912228 | ||||||
Dog | neuropeptide Y | VGNC:43936 | 475257 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | neuropeptide Y | |||||
Macaque | neuropeptide Y | |||||
Mouse | ||||||
Rat | ||||||
Dog | neuropeptide Y | |||||
Publication Statistics
PubMed Score 8728.70
PubMed score by year
PubTator Score 2100.16
PubTator score by year
Related Publications
Text Mined References (299)
GeneRif Annotations (213)
Items per page:
0 of 0
PMID | Year | Title |
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