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Tbio
NPW
Neuropeptide W

Protein Summary
Description
Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329610
  • ENSP00000330070
  • ENSG00000183971

Symbol
  • PPL8
  • PPNPW
  • L8
  • L8C
  • PPL8
  • PPNPW
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.47
cell line
0.43
cell type or tissue
0.39
disease
0.37
tissue
0.37


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.03   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.03   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (232)
NPBWR2
Tbio
Family:  GPCR
Novelty:  0.05283415
Score:  0.994
Data Source:  Reactome,STRINGDB
NPBWR1
Tchem
Family:  GPCR
Novelty:  0.03520069
Score:  0.994
Data Source:  Reactome,STRINGDB
NPB
Tdark
Novelty:  0.00936692
Score:  0.991
Data Source:  STRINGDB
GNG13
Tbio
Novelty:  0.13011919
Score:  0.946
Data Source:  STRINGDB
SSTR4
Tclin
Family:  GPCR
Novelty:  0.01528237
Score:  0.938
Data Source:  STRINGDB
NMS
Tbio
Novelty:  0.03324369
Score:  0.937
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.936
Data Source:  STRINGDB
SSTR1
Tclin
Family:  GPCR
Novelty:  0.00588024
Score:  0.936
Data Source:  STRINGDB
OPRK1
Tclin
Family:  GPCR
Novelty:  0.00171044
Score:  0.935
Data Source:  STRINGDB
SSTR5
Tclin
Family:  GPCR
Novelty:  0.00568309
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
3
3
92
glomerular filtration rate
3
3
3
82.9
appendicular lean mass
3
1
3
81.2
serum gamma-glutamyl transferase measurement
1
1
1
81
BMI-adjusted waist circumference
2
3
4
80.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
3
92
glomerular filtration rate
3
82.9
appendicular lean mass
3
81.2
serum gamma-glutamyl transferase measurement
1
81
BMI-adjusted waist circumference
4
80.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuropeptide W
VGNC:13752
101056810
Macaque
neuropeptide W
694262
Mouse
MGI:2685781
381073
Rat
RGD:727858
259224
Cow
neuropeptide W [Source:HGNC Symbol;Acc:HGNC:30509]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuropeptide W
Macaque
neuropeptide W
Mouse
Rat
Cow
neuropeptide W [Source:HGNC Symbol;Acc:HGNC:30509]
Publication Statistics
PubMed Score 42.03
PubMed score by year
PubTator Score 24.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title