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Tdark
NPVF
Pro-FMRFamide-related neuropeptide VF

Protein Summary
Description
Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide RFRP-1 induces secretion of prolactin in rats. Neuropeptide NPVF blocks morphine-induced analgesia.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222674
  • ENSP00000222674
  • ENSG00000105954

Symbol
  • C7orf9
  • RFRP
  • RFRP
  • C7orf9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.6
cell type or tissue
0.54
gene perturbation
0.51
transcription factor
0.47
metabolite
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.35   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.35   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
NPFF
Tbio
Novelty:  0.00489546
Score:  0.899
Data Source:  STRINGDB
NPFFR1
Tchem
Family:  GPCR
Novelty:  0.01950099
Score:  0.863
Data Source:  STRINGDB
GNRH1
Tbio
Novelty:  0.00020807
Score:  0.859
Data Source:  STRINGDB
QRFP
Tbio
Novelty:  0.02210773
Score:  0.801
Data Source:  STRINGDB
KISS1
Tbio
Novelty:  0.00096537
Score:  0.798
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.769
Data Source:  STRINGDB
NPFFR2
Tchem
Family:  GPCR
Novelty:  0.01703886
Score:  0.743
Data Source:  STRINGDB
KISS1R
Tchem
Family:  GPCR
Novelty:  0.0026282
Score:  0.713
Data Source:  STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.704
Data Source:  STRINGDB
INSL4
Tbio
Novelty:  0.03610293
Score:  0.688
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
1
1
2.5
BMI-adjusted hip circumference
1
1
1
1.3
body fat percentage
1
1
2
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
2.5
BMI-adjusted hip circumference
1
1.3
body fat percentage
2
0.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuropeptide VF precursor
VGNC:4447
744893
Macaque
neuropeptide VF precursor
613271
Mouse
MGI:1926488
60531
Rat
RGD:61815
60570
Dog
neuropeptide VF precursor
VGNC:43935
100682920
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuropeptide VF precursor
Macaque
neuropeptide VF precursor
Mouse
Rat
Dog
neuropeptide VF precursor
Publication Statistics
PubMed Score 113.35
PubMed score by year
PubTator Score 110.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title