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Tbio
NPTXR
Neuronal pentraxin receptor

Protein Summary
Description
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000640136
  • ENSP00000492079
  • ENSG00000221890

Symbol
  • NPR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
microRNA
0.63
PubMedID
0.63
transcription factor binding site profile
0.61
tissue
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1106.12   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1106.12   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
PHC1
Tbio
Novelty:  0.01530622
p_int:  0.999999908
p_ni:  2.1e-8
p_wrong:  7e-8
Score:  0.239
Data Source:  BioPlex,STRINGDB
CYB5D2
Tbio
Novelty:  0.23122479
p_int:  0.999995395
p_ni:  0.000004598
p_wrong:  6e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
SFTPC
Tbio
Novelty:  0.00154396
p_int:  0.999982197
p_ni:  5.6e-8
p_wrong:  0.000017746
Score:  0.193
Data Source:  BioPlex,STRINGDB
NPTX2
Tbio
Novelty:  0.00686292
p_int:  0.998107701
p_ni:  0.001889646
p_wrong:  0.000002653
Score:  0.453
Data Source:  BioPlex,STRINGDB
RCN2
Tbio
Novelty:  0.03883858
Score:  0.804
Data Source:  STRINGDB
NPR1
Tclin
Family:  Kinase
Novelty:  0.00170829
Score:  0.787
Data Source:  STRINGDB
NPR2
Tclin
Family:  Kinase
Novelty:  0.00418989
Score:  0.752
Data Source:  STRINGDB
NPR3
Tchem
Novelty:  0.00227442
Score:  0.752
Data Source:  STRINGDB
NPPC
Tbio
Novelty:  0.00114199
Score:  0.683
Data Source:  STRINGDB
HPR
Tbio
Novelty:  0.00327853
Score:  0.627
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
85.9
1
1
0
1.2
79.5
mathematical ability
3
2
3
67.4
BMI-adjusted hip circumference
1
1
1
40.4
urinary bladder carcinoma
2
1
0
1.2
27.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
85.9
0
1.2
79.5
mathematical ability
3
67.4
BMI-adjusted hip circumference
1
40.4
urinary bladder carcinoma
0
1.2
27.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuronal pentraxin receptor
VGNC:5288
744373
Mouse
MGI:1920590
73340
Rat
RGD:628898
81005
Xenopus
neuronal pentraxin receptor
XB-GENE-983806
100158646
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuronal pentraxin receptor
Mouse
Rat
Xenopus
neuronal pentraxin receptor
Publication Statistics
PubMed Score 1106.12
PubMed score by year
PubTator Score 82.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title