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Tbio
NPTX2
Neuronal pentraxin-2

Protein Summary
Description
Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity). This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265634
  • ENSP00000265634
  • ENSG00000106236

Symbol
  • NP2
  • NARP
  • NP-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.9
kinase perturbation
0.81
disease perturbation
0.62
transcription factor
0.62
disease
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.78   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.78   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
CYB5D2
Tbio
Novelty:  0.23122479
p_int:  0.999999992
p_ni:  7e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
NPTX1
Tbio
Novelty:  0.02872516
p_int:  0.999919176
p_ni:  0.000080824
Data Source:  BioPlex
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.999779561
p_ni:  0.000192625
p_wrong:  0.000027814
Data Source:  BioPlex
NDE1
Tbio
Novelty:  0.00567438
p_int:  0.999570274
p_ni:  0.000429726
Data Source:  BioPlex
NPTXR
Tbio
Novelty:  0.00727951
p_int:  0.998107701
p_ni:  0.001889646
p_wrong:  0.000002653
Score:  0.453
Data Source:  BioPlex,STRINGDB
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.997789094
p_ni:  0.002210906
Data Source:  BioPlex
RGPD5
Tbio
Novelty:  0.13776125
p_int:  0.98018775
p_ni:  0.01981225
Data Source:  BioPlex
OS9
Tbio
Novelty:  0.01490339
p_int:  0.959232874
p_ni:  0.040764902
p_wrong:  0.000002224
Data Source:  BioPlex
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
p_int:  0.936298848
p_ni:  0.063701152
Data Source:  BioPlex
BATF3
Tbio
Family:  TF
Novelty:  0.01554987
p_int:  0.877975114
p_ni:  0.001032095
p_wrong:  0.120992791
Score:  0.188
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuronal pentraxin 2
VGNC:8704
463562
Macaque
neuronal pentraxin 2
718428
Mouse
MGI:1858209
53324
Rat
RGD:1309447
288475
Dog
neuronal pentraxin 2
VGNC:43934
100855792
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuronal pentraxin 2
Macaque
neuronal pentraxin 2
Mouse
Rat
Dog
neuronal pentraxin 2
Publication Statistics
PubMed Score 154.78
PubMed score by year
PubTator Score 144.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title