NPTX1
Neuronal pentraxin-1
Protein Summary
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. [provided by RefSeq, Jul 2008]
- ENST00000306773
- ENSP00000307549
- ENSG00000171246
- NP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.83 | ||
PubMedID | 0.82 | ||
microRNA | 0.75 | ||
gene perturbation | 0.72 | ||
transcription factor binding site profile | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.97 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 364 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.97 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 364 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (92)
NECTIN3
Novelty: 0.01288113
p_int: 0.999802626
p_ni: 0.000197374
Score: 0.154
Data Source: BioPlex,STRINGDB
ADAM18
Family: Enzyme
Novelty: 0.22622379
p_int: 0.994908817
p_ni: 0.005091183
Data Source: BioPlex
WNT7A
Novelty: 0.00421662
p_int: 0.994287707
p_ni: 0.005712293
Score: 0.228
Data Source: BioPlex,STRINGDB
LYZL2
Family: Enzyme
Novelty: 0.50542161
p_int: 0.994204671
p_ni: 0.005795329
Data Source: BioPlex
LYPD4
Novelty: 0.00381728
p_int: 0.993743615
p_ni: 0.006256367
p_wrong: 1.8e-8
Data Source: BioPlex
LYPD1
Novelty: 0.10740408
p_int: 0.9880076
p_ni: 0.011992399
p_wrong: 1e-9
Score: 0.24
Data Source: BioPlex,STRINGDB
CD96
Novelty: 0.02087722
p_int: 0.987527411
p_ni: 0.012472588
p_wrong: 1e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (1)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 3 | 2 | 3 | 45.6 | |||||
thalamus volume | 1 | 1 | 0 | 6.4 | 44.2 | ||||
pulse pressure measurement | 1 | 1 | 1 | 40.7 | |||||
aspartate aminotransferase measurement | 1 | 1 | 0 | 6.2 | 38.8 | ||||
1 | 1 | 1 | 26.6 | ||||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 3 | 45.6 | |||||
thalamus volume | 0 | 6.4 | 44.2 | ||||
pulse pressure measurement | 1 | 40.7 | |||||
aspartate aminotransferase measurement | 0 | 6.2 | 38.8 | ||||
1 | 26.6 | ||||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | neuronal pentraxin 1 | VGNC:9480 | 468350 | |||||
Macaque | neuronal pentraxin 1 | 718259 | ||||||
Mouse | MGI:107811 | 18164 | ||||||
Rat | RGD:628894 | 266777 | ||||||
Dog | neuronal pentraxin 1 | VGNC:43933 | 483356 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | neuronal pentraxin 1 | |||||
Macaque | neuronal pentraxin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | neuronal pentraxin 1 | |||||
Publication Statistics
PubMed Score 43.97
PubMed score by year
PubTator Score 155.39
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
|---|