Tbio NPTX1 Neuronal pentraxin-1

Protein Summary

Description

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15818
• B3KXH3
• Q5FWE6
• NP1

Gene Name

• NPTX1

Ensembl ID

• ENST00000306773
• ENSP00000307549
• ENSG00000171246

Symbol

• NP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.83
PubMedID	0.82
microRNA	0.75
gene perturbation	0.72
transcription factor binding site profile	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.29   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 364   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.29   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0