You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NPSR1
Neuropeptide S receptor

Protein Summary
Description
G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases. This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359791
  • ENSP00000352839
  • ENSG00000187258
  • ENST00000360581
  • ENSP00000353788
  • ENST00000381539
  • ENSP00000370950
  • ENST00000381542
  • ENSP00000370953
  • ENST00000381544
  • ENSP00000370955
  • ENST00000381553
  • ENSP00000370965
  • ENST00000396095
  • ENSP00000379402
  • ENST00000465305
  • ENSP00000434955
  • ENST00000531252
  • ENSP00000433258

Symbol
  • GPR154
  • GPRA
  • PGR14
  • GPRA
  • NPSR
  • VRR1
  • ASRT2
  • PGR14
  • GPR154
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.66
protein domain
0.58
phenotype
0.54
tissue
0.54
disease
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.86   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.86   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (551)
NPS
Tbio
Novelty:  0.00692108
Score:  0.982
Data Source:  Reactome,STRINGDB
CASR
Tclin
Family:  GPCR
Novelty:  0.00061316
Score:  0.967
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.96
Data Source:  STRINGDB
P35544
Tbio
Novelty:  0.01170009
Score:  0.959
Data Source:  STRINGDB
P62861
Tbio
Novelty:  0.01170009
Score:  0.959
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.958
Data Source:  STRINGDB
CRHR1
Tclin
Family:  GPCR
Novelty:  0.00101773
Score:  0.956
Data Source:  STRINGDB
P01258
Tbio
Novelty:  0.00010496
Score:  0.953
Data Source:  STRINGDB
P06881
Tclin
Novelty:  0.00010496
Score:  0.953
Data Source:  STRINGDB
PTH
Tbio
Novelty:  0.00003263
Score:  0.951
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
2
2
37.4
exercise
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
37.4
exercise
1
13.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuropeptide S receptor 1
VGNC:4446
747277
Macaque
neuropeptide S receptor 1
574355
Mouse
MGI:2441738
319239
Rat
RGD:1564154
300458
Dog
neuropeptide S receptor 1
VGNC:54789
482394
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuropeptide S receptor 1
Macaque
neuropeptide S receptor 1
Mouse
Rat
Dog
neuropeptide S receptor 1
Publication Statistics
PubMed Score 279.86
PubMed score by year
PubTator Score 96.18
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title