Tbio NPRL2 GATOR complex protein NPRL2

Protein Summary

Description

As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.

Uniprot Accession IDs

• Q8WTW4
• A8K831
• Q6FGS2
• Q9Y249
• Q9Y497

Gene Name

• NPRL2

Ensembl ID

• ENST00000232501
• ENSP00000232501
• ENSG00000114388

Symbol

• TUSC4
• NPR2
• NPR2L
• TUSC4
• FFEVF2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.71
transcription factor binding site profile	0.69
histone modification site profile	0.56
tissue sample	0.55
molecular function	0.53

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Gator Complex Protein Nprl2

Protein / Nucleic Acid Binding / Nuclease / Gator Complex Protein Nprl2

DTO Classes

Protein / Enzyme / Nuclease / Gator Complex Protein Nprl2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.94   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 267   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.94   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (77)

Explore Interacting Targets

1 – 10 of 77

• See Interactions on String-DB

DEPDC5

Tbio

Novelty:  0.0177511

p_int:  1

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

NPRL3

Tbio

Family:  Enzyme

Novelty:  0.0110744

p_int:  0.999999998

p_ni:  2e-9

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

ZBTB5

Tbio

Novelty:  0.50774653

p_int:  0.999998959

p_ni:  0.00000104

Score:  0.214

Data Source:  BioPlex,STRINGDB

BMT2

Tbio

Family:  Enzyme

Novelty:  0.05916379

p_int:  0.999993196

p_ni:  0.000006802

p_wrong:  2e-9

Score:  0.704

Data Source:  BioPlex,Reactome,STRINGDB

ZNF414

Tdark

Novelty:  1.29024829

p_int:  0.999887821

p_ni:  0.000112179

Score:  0.513

Data Source:  BioPlex,STRINGDB

APPBP2

Tbio

Novelty:  0.14742368

p_int:  0.971840986

p_ni:  0.028159011

p_wrong:  3e-9

Score:  0.197

Data Source:  BioPlex,STRINGDB

LRCH2

Tdark

Novelty:  1.90908316

p_int:  0.929402196

p_ni:  0.07005366

p_wrong:  0.000544144

Score:  0.188

Data Source:  BioPlex,STRINGDB

MIOS

Tdark

Novelty:  0.04252507

Score:  0.999

Data Source:  STRINGDB

SEH1L

Tbio

Novelty:  0.03666501

Score:  0.999

Data Source:  STRINGDB

WDR24

Tdark

Novelty:  0.48411996

Score:  0.999

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

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Data Source	Name	Explore in Pharos	Explore in Source
KEGG	mTOR signaling pathway	152 targets	path:hsa04150

Name	Explore in Pharos	Explore in Source
mTOR signaling pathway	152 targets	path:hsa04150

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (2)

Components (2)

Processes (6)

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1 – 2 of 2

GO Term	Evidence	Assigned by
protein kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
GTPase activator activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (18)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 18

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	3	5	11		99.2
reticulocyte count	EFO_0007986	2	4	8		98.7
mean reticulocyte volume	EFO_0010701	1	1	1		85.1
chronotype measurement	EFO_0008328	1	1	0	1	66.8
macrophage inflammatory protein 1b measurement	EFO_0008219	1	2	2		66.2

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	11		99.2
reticulocyte count	EFO_0007986	8		98.7
mean reticulocyte volume	EFO_0010701	1		85.1
chronotype measurement	EFO_0008328	0	1	66.8
macrophage inflammatory protein 1b measurement	EFO_0008219	2		66.2

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Disease mutation
Epilepsy
GTPase activation
Lysosome
Membrane
Reference proteome
Tumor suppressor

GWAS Trait Find Similar Targets

No Header	No Header
basophil count
basophil percentage of leukocytes
BMI-adjusted waist circumference
chronotype measurement
cigarettes per day measurement
cognitive function measurement
diastolic blood pressure
feeling tense measurement
intelligence
lymphocyte percentage of leukocytes

MGI Phenotype Find Similar Targets

No Header	No Header
embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NPR2 like, GATOR1 complex subunit		460393
Macaque	NPR2 like, GATOR1 complex subunit		701924
Mouse	nitrogen permease regulator-like 2	MGI:1914482	56032
Rat	NPR2-like, GATOR1 complex subunit	RGD:1308927	363138
Dog	NPR2 like, GATOR1 complex subunit	VGNC:43930	476614

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NPR2 like, GATOR1 complex subunit
Macaque	NPR2 like, GATOR1 complex subunit
Mouse	nitrogen permease regulator-like 2
Rat	NPR2-like, GATOR1 complex subunit
Dog	NPR2 like, GATOR1 complex subunit

Publication Statistics

PubMed Score 41.94

PubMed score by year

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PubTator Score 19.27

PubTator score by year

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Related Publications

Text Mined References (34)

GeneRif Annotations (20)

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PMID	Year	Title