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Tclin
NPR1
Atrial natriuretic peptide receptor 1

Protein Summary
Description
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368680
  • ENSP00000357669
  • ENSG00000169418

Symbol
  • ANPRA
  • ANPa
  • NPRA
  • ANPRA
  • GUC2A
  • GUCY2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.99
biological process
0.96
hub protein
0.85
gene perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 641.86   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 641.86   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (10)
CHEMBL4102000
Rendered image for CHEMBL4102000
CHEMBL294263
Rendered image for CHEMBL294263
CHEMBL61383
Rendered image for CHEMBL61383
CHEMBL4090153
Rendered image for CHEMBL4090153
CHEMBL4206902
Rendered image for CHEMBL4206902
CHEMBL4099832
Rendered image for CHEMBL4099832
CHEMBL4061575
Rendered image for CHEMBL4061575
CHEMBL4089697
Rendered image for CHEMBL4089697
CHEMBL4097422
Rendered image for CHEMBL4097422
Protein-Protein Interactions (152)
NPPA
Tchem
Novelty:  0.00046693
Score:  0.997
Data Source:  Reactome,STRINGDB
NPPC
Tbio
Novelty:  0.00114199
Score:  0.948
Data Source:  STRINGDB
PDE5A
Tclin
Family:  Enzyme
Novelty:  0.00032205
Score:  0.901
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.9
Data Source:  STRINGDB
NUDT2
Tbio
Family:  Enzyme
Novelty:  0.0201004
Score:  0.9
Data Source:  STRINGDB
PRKG1
Tchem
Family:  Kinase
Novelty:  0.0014943
Score:  0.857
Data Source:  STRINGDB
NPPB
Tbio
Novelty:  0.00024947
Score:  0.826
Data Source:  STRINGDB
GCH1
Tbio
Family:  Enzyme
Novelty:  0.0025793
Score:  0.815
Data Source:  STRINGDB
NPR2
Tbio
Family:  Kinase
Novelty:  0.00418989
Score:  0.807
Data Source:  STRINGDB
MOCS1
Tclin
Novelty:  0.02785369
Score:  0.806
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (52)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Physiological factors
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Physiological factors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diet measurement
3
2
3
71.8
body height
1
1
1
54.4
platelet crit
1
1
1
24.4
monocyte count
1
1
1
9
number of children ever born measurement
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diet measurement
3
71.8
body height
1
54.4
platelet crit
1
24.4
monocyte count
1
9
number of children ever born measurement
1
2.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
natriuretic peptide receptor 1
VGNC:1419
457329
Macaque
natriuretic peptide receptor 1
715598
Mouse
MGI:97371
18160
Rat
RGD:3195
24603
Dog
natriuretic peptide receptor 1
VGNC:43928
490455
Species
Name
OMA
EggNOG
Inparanoid
Chimp
natriuretic peptide receptor 1
Macaque
natriuretic peptide receptor 1
Mouse
Rat
Dog
natriuretic peptide receptor 1
Publication Statistics
PubMed Score 641.86
PubMed score by year
PubTator Score 199.27
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title