Tclin NPR1 Atrial natriuretic peptide receptor 1

Protein Summary

Description

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

Uniprot Accession IDs

• P16066
• B0ZBF0
• Q5SR08
• Q6P4Q3

Gene Name

• NPR1

Ensembl ID

• ENST00000368680
• ENSP00000357669
• ENSG00000169418

Symbol

• ANPRA
• ANPa
• NPRA
• ANPRA
• GUC2A
• GUCY2A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.99
biological process	0.96
hub protein	0.85
gene perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Lyase / Cyclase / Guanylate Cyclase / Atrial Natriuretic Peptide Receptor 1

Protein / Lyase / Cyclase / Adenylate Cyclase / Atrial Natriuretic Peptide Receptor 1

DTO Classes

Protein / Kinase / Protein Kinase / Rgc Group / Rgc Family / Atrial Natriuretic Peptide Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 711.84   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 280   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 711.84   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1