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Tbio
NPPC
C-type natriuretic peptide

Protein Summary
Description
Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295440
  • ENSP00000295440
  • ENSG00000163273
  • ENST00000409852
  • ENSP00000387159

Symbol
  • CNP2
  • CNP
  • CNP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
gene perturbation
0.94
histone modification site profile
0.81
cell type or tissue
0.75
biological term
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 787.99   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 787.99   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
NPR2
Tbio
Family:  Kinase
Novelty:  0.00418989
Score:  0.997
Data Source:  Reactome,STRINGDB
NPR3
Tchem
Novelty:  0.00227442
Score:  0.97
Data Source:  STRINGDB
NPR1
Tclin
Family:  Kinase
Novelty:  0.00170829
Score:  0.948
Data Source:  STRINGDB
NPPA
Tchem
Novelty:  0.00046693
Score:  0.804
Data Source:  STRINGDB
NPPB
Tbio
Novelty:  0.00024947
Score:  0.788
Data Source:  STRINGDB
MME
Tclin
Family:  Enzyme
Novelty:  0.00019144
Score:  0.729
Data Source:  STRINGDB
GUCY2C
Tclin
Family:  Kinase
Novelty:  0.00209733
Score:  0.719
Data Source:  STRINGDB
NPTXR
Tbio
Novelty:  0.00727951
Score:  0.683
Data Source:  STRINGDB
CNP
Tbio
Family:  Enzyme
Novelty:  0.00566142
Score:  0.677
Data Source:  STRINGDB
GUCY2F
Tbio
Family:  Kinase
Novelty:  0.03634576
Score:  0.673
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Physiological factors
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Physiological factors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
3
3
91.9
BMI-adjusted waist circumference
3
3
8
69.5
BMI-adjusted hip circumference
2
4
5
58.3
balding measurement
1
1
1
9.1
red blood cell density measurement
1
1
1
7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
91.9
BMI-adjusted waist circumference
8
69.5
BMI-adjusted hip circumference
5
58.3
balding measurement
1
9.1
red blood cell density measurement
1
7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
natriuretic peptide C
VGNC:14324
740147
Macaque
natriuretic peptide C
717026
Mouse
MGI:97369
18159
Rat
RGD:620850
114593
Dog
natriuretic peptide C
VGNC:43927
610169
Species
Name
OMA
EggNOG
Inparanoid
Chimp
natriuretic peptide C
Macaque
natriuretic peptide C
Mouse
Rat
Dog
natriuretic peptide C
Publication Statistics
PubMed Score 787.99
PubMed score by year
PubTator Score 362.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title