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Tbio
NPM2
Nucleoplasmin-2

Protein Summary
Description
Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289820
  • ENSP00000289820
  • ENSG00000158806
  • ENST00000381530
  • ENSP00000370941
  • ENST00000397940
  • ENSP00000381032
  • ENST00000518119
  • ENSP00000427741
  • ENST00000521157
  • ENSP00000429413
  • ENST00000615914
  • ENSP00000481018
  • ENST00000621538
  • ENSP00000481077
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
histone modification site profile
0.64
cellular component
0.63
biological process
0.6
tissue sample
0.55


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.98   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.98   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
NPM1
Tbio
Novelty:  0.0005485
p_int:  0.999923046
p_ni:  0.000076954
Score:  0.605
Data Source:  BioPlex,STRINGDB
GOPC
Tchem
Novelty:  0.01110168
p_int:  0.99689185
p_ni:  0.00310815
Score:  0.163
Data Source:  BioPlex,STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
p_int:  0.988918034
p_ni:  0.011081966
Score:  0.211
Data Source:  BioPlex,STRINGDB
NPM3
Tbio
Novelty:  0.11783423
p_int:  0.984036617
p_ni:  0.015566099
p_wrong:  0.000397284
Score:  0.993
Data Source:  BioPlex,STRINGDB
ODF2L
Tdark
Novelty:  0.56986705
p_int:  0.946090388
p_ni:  0.010658789
p_wrong:  0.043250823
Score:  0.199
Data Source:  BioPlex,STRINGDB
MTG2
Tbio
Family:  Enzyme
Novelty:  0.06104792
p_int:  0.790689454
p_ni:  0.005284306
p_wrong:  0.20402624
Data Source:  BioPlex
ZAR1
Tbio
Novelty:  0.02026945
Score:  0.878
Data Source:  STRINGDB
SNU13
Tbio
Novelty:  0.01613497
Score:  0.853
Data Source:  STRINGDB
H1FOO
Tbio
Novelty:  0.02189067
Score:  0.809
Data Source:  STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
Score:  0.764
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
3
4
95.7
serum gamma-glutamyl transferase measurement
3
3
3
94.3
2
3
0
1.1
91.2
mean corpuscular hemoglobin concentration
2
2
2
86.4
mean reticulocyte volume
1
2
2
86.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
95.7
serum gamma-glutamyl transferase measurement
3
94.3
0
1.1
91.2
mean corpuscular hemoglobin concentration
2
86.4
mean reticulocyte volume
2
86.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleophosmin/nucleoplasmin 2
VGNC:10223
464038
Macaque
nucleophosmin/nucleoplasmin 2
715448
Mouse
MGI:1890811
328440
Rat
RGD:727816
290359
Horse
nucleophosmin/nucleoplasmin 2
VGNC:50733
100056399
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleophosmin/nucleoplasmin 2
Macaque
nucleophosmin/nucleoplasmin 2
Mouse
Rat
Horse
nucleophosmin/nucleoplasmin 2
Publication Statistics
PubMed Score 34.98
PubMed score by year
PubTator Score 5.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title