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Tbio
NPLOC4
Nuclear protein localization protein 4 homolog

Protein Summary
Description
The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331134
  • ENSP00000331487
  • ENSG00000182446
  • ENST00000374747
  • ENSP00000363879

Symbol
  • KIAA1499
  • NPL4
  • NPL4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
protein domain
0.85
interacting protein
0.73
virus perturbation
0.72
transcription factor binding site profile
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.38   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.38   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (237)
SLC17A2
Tdark
Family:  Transporter
Novelty:  0.23941275
p_int:  0.983794219
p_ni:  0.01620578
p_wrong:  1e-9
Data Source:  BioPlex
TMEM31
Tdark
Novelty:  0.65381391
p_int:  0.970037584
p_ni:  0.029962416
Data Source:  BioPlex
PTCHD3
Tbio
Novelty:  0.00081643
p_int:  0.948518732
p_ni:  0.051481268
Data Source:  BioPlex
ATG9A
Tbio
Novelty:  0.01995033
p_int:  0.945401317
p_ni:  0.054598683
Score:  0.187
Data Source:  BioPlex,STRINGDB
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.911058469
p_ni:  0.088941531
Data Source:  BioPlex
KDELR1
Tbio
Novelty:  0.0036468
p_int:  0.898348719
p_ni:  0.101651281
Score:  0.218
Data Source:  BioPlex,STRINGDB
KCNK16
Tbio
Family:  IC
Novelty:  0.09168043
p_int:  0.838557866
p_ni:  0.161442134
Score:  0.163
Data Source:  BioPlex,STRINGDB
CYP19A1
Tclin
Family:  Enzyme
Novelty:  0.0003187
p_int:  0.831892851
p_ni:  0.168107149
Score:  0.241
Data Source:  BioPlex,STRINGDB
KCNC4
Tclin
Family:  IC
Novelty:  0.01215128
p_int:  0.822848634
p_ni:  0.177151366
Data Source:  BioPlex
SLC22A15
Tdark
Family:  Transporter
Novelty:  0.22792289
p_int:  0.785776363
p_ni:  0.214223637
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
DNA Damage Bypass (R-HSA-73893)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Reactome
Translesion Synthesis by POLH
Reactome
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
Name
Explore in Pharos
Explore in Source
DNA Damage Bypass
DNA Repair
Translesion Synthesis by POLH
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
3
3
0
1.1
98
serum gamma-glutamyl transferase measurement
3
5
6
95.2
Myopia
3
3
0
1.2
92.7
refractive error
2
3
2
5.9
89.4
ganglion cell inner plexiform layer thickness measurement
1
1
1
87.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
98
serum gamma-glutamyl transferase measurement
6
95.2
Myopia
0
1.2
92.7
refractive error
2
5.9
89.4
ganglion cell inner plexiform layer thickness measurement
1
87.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NPL4 homolog, ubiquitin recognition factor
VGNC:10261
454960
Mouse
MGI:2679787
217365
Rat
RGD:620794
140639
Dog
NPL4 homolog, ubiquitin recognition factor
VGNC:43922
483363
Horse
NPL4 homolog, ubiquitin recognition factor
VGNC:20840
100055877
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NPL4 homolog, ubiquitin recognition factor
Mouse
Rat
Dog
NPL4 homolog, ubiquitin recognition factor
Horse
NPL4 homolog, ubiquitin recognition factor
Publication Statistics
PubMed Score 56.38
PubMed score by year
PubTator Score 34.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title