You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NPL
N-acetylneuraminate lyase

Protein Summary
Description
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity). This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258317
  • ENSP00000258317
  • ENSG00000135838
  • ENST00000367552
  • ENSP00000356523
  • ENST00000367553
  • ENSP00000356524
  • ENST00000367554
  • ENSP00000356525
  • ENST00000367555
  • ENSP00000356526

Symbol
  • C1orf13
  • NAL
  • C112
  • NPL1
  • C1orf13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.79
gene perturbation
0.72
PubMedID
0.71
microRNA
0.69


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.62   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.62   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
QPRT
Tbio
Family:  Enzyme
Novelty:  0.00781554
p_int:  0.99996304
p_ni:  0.000035757
p_wrong:  0.000001203
Score:  0.432
Data Source:  BioPlex,STRINGDB
RENBP
Tbio
Family:  Enzyme
Novelty:  0.02220005
Score:  0.971
Data Source:  STRINGDB
NANS
Tbio
Family:  Enzyme
Novelty:  0.00718044
Score:  0.965
Data Source:  STRINGDB
GNE
Tbio
Family:  Enzyme
Novelty:  0.00285751
Score:  0.957
Data Source:  STRINGDB
ENOSF1
Tbio
Family:  Enzyme
Novelty:  0.05583478
Score:  0.844
Data Source:  STRINGDB
ACD
Tbio
Novelty:  0.00517732
Score:  0.788
Data Source:  STRINGDB
ST8SIA5
Tdark
Family:  Enzyme
Novelty:  0.19468906
Score:  0.774
Data Source:  STRINGDB
CMAS
Tbio
Family:  Enzyme
Novelty:  0.04295627
Score:  0.748
Data Source:  STRINGDB
GNRH1
Tbio
Novelty:  0.00020807
Score:  0.737
Data Source:  STRINGDB
FUOM
Tbio
Family:  Enzyme
Novelty:  0.0562349
Score:  0.696
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Sialic acid metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Sialic acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
2
0
1.2
79.3
body height
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1.2
79.3
body height
1
0.5
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acetylneuraminate pyruvate lyase
VGNC:11566
457567
Macaque
N-acetylneuraminate pyruvate lyase
106994586
Mouse
MGI:1921341
74091
Rat
RGD:1549702
304860
Dog
N-acetylneuraminate pyruvate lyase
VGNC:43921
490313
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acetylneuraminate pyruvate lyase
Macaque
N-acetylneuraminate pyruvate lyase
Mouse
Rat
Dog
N-acetylneuraminate pyruvate lyase
Publication Statistics
PubMed Score 102.62
PubMed score by year
PubTator Score 146.12
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title