Protein Summary
Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
- ENST00000367615
- ENSP00000356587
- ENSG00000116218
- ENST00000367616
- ENSP00000356588
- PDCN
- SRN1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.75 | ||
cellular component | 0.7 | ||
disease | 0.67 | ||
cell type or tissue | 0.62 | ||
gene perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 473.49 (req: < 5)
Gene RIFs: 109 (req: <= 3)
Antibodies: 108 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 473.49 (req: >= 5)
Gene RIFs: 109 (req: > 3)
Antibodies: 108 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (104)
Nearest Tclin Targets
Pathways (6)
PathwayCommons (1)
WikiPathways (5)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: pid | Nephrin/Neph1 signaling in the kidney podocyte | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Nephrin/Neph1 signaling in the kidney podocyte | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Components (9)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
thrombomodulin measurement | 1 | 1 | 1 | 68.6 | |||||
tumor necrosis factor receptor II measurement | 1 | 1 | 1 | 64.4 | |||||
diastolic blood pressure | 1 | 1 | 1 | 44.2 | |||||
vitamin D measurement | 1 | 1 | 1 | 26.1 | |||||
household income | 1 | 1 | 1 | 24.5 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
thrombomodulin measurement | 1 | 68.6 | |||||
tumor necrosis factor receptor II measurement | 1 | 64.4 | |||||
diastolic blood pressure | 1 | 44.2 | |||||
vitamin D measurement | 1 | 26.1 | |||||
household income | 1 | 24.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | NPHS2, podocin | VGNC:8438 | 100615219 | |||||
Macaque | NPHS2, podocin | 100430826 | ||||||
Mouse | MGI:2157018 | 170484 | ||||||
Rat | RGD:620461 | 170672 | ||||||
Dog | NPHS2, podocin | VGNC:54153 | 490323 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | NPHS2, podocin | |||||
Macaque | NPHS2, podocin | |||||
Mouse | ||||||
Rat | ||||||
Dog | NPHS2, podocin | |||||
Publication Statistics
PubMed Score 473.49
PubMed score by year
PubTator Score 302.57
PubTator score by year
Related Publications
Text Mined References (137)
GeneRif Annotations (109)
Items per page:
0 of 0
PMID | Year | Title |
|---|