Tbio NPHS2 Podocin

Protein Summary

Description

Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q9NP85
• B1AM32
• B1AM33
• Q8N6Q5

Gene Name

• NPHS2

Ensembl ID

• ENST00000367615
• ENSP00000356587
• ENSG00000116218
• ENST00000367616
• ENSP00000356588

Symbol

• PDCN
• SRN1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.75
cellular component	0.7
disease	0.67
cell type or tissue	0.62
gene perturbation	0.62

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Podocin

Protein / ... / Protease Inhibitor / Podocin

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Podocin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 530.41   (req: < 5)

Gene RIFs: 133   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 530.41   (req: >= 5)

Gene RIFs: 133   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0