Protein Summary
Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (Pu ...more
- ENST00000378156
- ENSP00000367398
- ENSG00000131697
- ENST00000489180
- ENSP00000423747
- ENST00000622020
- ENSP00000481831
- KIAA0673
- POC10
- SLSN4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cellular component | 0.83 | ||
transcription factor | 0.78 | ||
transcription factor binding site profile | 0.77 | ||
histone modification site profile | 0.74 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.57 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 101 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.57 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 101 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (185)
RPGR
Family: Enzyme
Novelty: 0.002733
p_int: 0.999999949
p_ni: 4.3e-8
p_wrong: 8e-9
Score: 0.972
Data Source: BioPlex,STRINGDB
SSSCA1
Novelty: 0.53523038
p_int: 0.99992528
p_ni: 0.000073593
p_wrong: 0.000001127
Data Source: BioPlex
SKAP1
Family: Enzyme
Novelty: 0.03753848
p_int: 0.999500421
p_ni: 0.000481193
p_wrong: 0.000018387
Score: 0.186
Data Source: BioPlex,STRINGDB
DNAJC7
Novelty: 0.02133191
p_int: 0.867278217
p_ni: 0.000721146
p_wrong: 0.132000637
Score: 0.173
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (5)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Anchoring of the basal body to the plasma membrane | ||||
Reactome | Cilium Assembly | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Hippo | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Anchoring of the basal body to the plasma membrane | ||||
Cilium Assembly | ||||
Organelle biogenesis and maintenance | ||||
Signal Transduction | ||||
Signaling by Hippo | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (1)
Components (9)
Processes (12)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | nephrocystin 4 | 720707 | ||||||
Mouse | MGI:2384210 | 260305 | ||||||
Rat | RGD:1560172 | 313749 | ||||||
Dog | nephrocystin 4 | VGNC:43920 | 489625 | |||||
Horse | nephrocystin 4 | VGNC:20838 | 100059842 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | nephrocystin 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nephrocystin 4 | |||||
Horse | nephrocystin 4 | |||||
Publication Statistics
PubMed Score 40.57
PubMed score by year
PubTator Score 26.47
PubTator score by year
Related Publications
Text Mined References (42)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
---|