Protein Summary
Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. This gene encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain. The encoded protein interacts with nephrocystin, it is required for normal ciliary development, and it functions in renal tubular development. Mutations in this gene are associated with nephronophthisis type 3, and also with renal-hepatic-pancreatic dysplasia, and Meckel syndrome type 7. Naturally occurring read-through transcripts exist between this gene and the downstream ACAD11 (acyl-CoA dehydrogenase family, member 11) gene. [provided by RefSeq, Feb 2011]
- ENST00000337331
- ENSP00000338766
- ENSG00000113971
- ENST00000383282
- ENSP00000372769
- KIAA2000
- MKS7
- NPH3
- RHPD
- RHPD1
- SLSN3
- CFAP31
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.81 | ||
histone modification site profile | 0.76 | ||
tissue sample | 0.67 | ||
biological process | 0.64 | ||
phenotype | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.6 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 95 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.6 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 95 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (99)
SNX11
Novelty: 0.21586113
p_int: 0.999999961
p_ni: 3.9e-8
Score: 0.193
Data Source: BioPlex,STRINGDB
CREB3
Family: TF
Novelty: 0.00424318
p_int: 0.999980996
p_ni: 0.000019004
Score: 0.183
Data Source: BioPlex,STRINGDB
BAP1
Family: Enzyme
Novelty: 0.00501435
p_int: 0.999736765
p_ni: 0.000263235
Data Source: BioPlex
KLHL29
Novelty: 0.72596897
p_int: 0.999642835
p_ni: 0.000357165
Score: 0.211
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (4)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cargo trafficking to the periciliary membrane | ||||
Reactome | Cilium Assembly | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Reactome | Trafficking of myristoylated proteins to the cilium | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cargo trafficking to the periciliary membrane | ||||
Cilium Assembly | ||||
Organelle biogenesis and maintenance | ||||
Trafficking of myristoylated proteins to the cilium | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Components (2)
Processes (20)
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 1 | 1 | 1 | 63.1 | |||||
apolipoprotein B measurement | 1 | 1 | 1 | 60.5 | |||||
total cholesterol measurement | 1 | 1 | 1 | 51.4 | |||||
alkaline phosphatase measurement | 1 | 1 | 0 | 6.7 | 48.5 | ||||
urate measurement | 1 | 1 | 1 | 44.2 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 1 | 63.1 | |||||
apolipoprotein B measurement | 1 | 60.5 | |||||
total cholesterol measurement | 1 | 51.4 | |||||
alkaline phosphatase measurement | 0 | 6.7 | 48.5 | ||||
urate measurement | 1 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | nephrocystin 3 | VGNC:10484 | 460706 | |||||
Mouse | MGI:1921275 | 74025 | ||||||
Rat | RGD:1563856 | 363126 | ||||||
Dog | nephrocystin 3 | VGNC:43919 | 100856544 | |||||
Horse | nephrocystin 3 | VGNC:20837 | 100064940 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | nephrocystin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nephrocystin 3 | |||||
Horse | nephrocystin 3 | |||||
Publication Statistics
PubMed Score 35.60
PubMed score by year
PubTator Score 30.52
PubTator score by year
Related Publications
Text Mined References (30)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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