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Tchem
NPC1
NPC intracellular cholesterol transporter 1

Protein Summary
Description
Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:9211849, PubMed:9927649, PubMed:10821832, PubMed:18772377, PubMed:27238017, PubMed:12554680). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:9211849, PubMed:9927649, PubMed:18772377, PubMed:19563754, PubMed:27238017, PubMed:28784760). Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (PubMed:19563754). Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). (Microbial infection) Acts as an endosomal entry receptor for ebolavirus. This gene encodes a large protein that re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269228
  • ENSP00000269228
  • ENSG00000141458

Symbol
  • NPC
  • POGZ
  • SLC65A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.98
disease perturbation
0.96
transcription factor perturbation
0.94
virus perturbation
0.92
biological process
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 806.09   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 356   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 806.09   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 356   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (100)
C15orf32
Tdark
Novelty:  8.4527027
p_int:  0.973730707
p_ni:  0.026269293
Data Source:  BioPlex
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.921133987
p_ni:  0.078866013
Score:  0.525
Data Source:  BioPlex,STRINGDB
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.828742138
p_ni:  0.171257862
Score:  0.169
Data Source:  BioPlex,STRINGDB
TPRA1
Tdark
Family:  GPCR
Novelty:  0.16743826
p_int:  0.817912066
p_ni:  0.182087934
Score:  0.187
Data Source:  BioPlex,STRINGDB
NPC2
Tbio
Novelty:  0.00342898
Score:  0.999
Data Source:  Reactome,STRINGDB
OSBPL5
Tbio
Novelty:  0.05262202
Score:  0.965
Data Source:  STRINGDB
TMEM97
Tchem
Novelty:  0.00597439
Score:  0.946
Data Source:  STRINGDB
GP2
Tbio
Novelty:  0.00126542
Score:  0.852
Data Source:  STRINGDB
SREBF2
Tchem
Family:  TF
Novelty:  0.00171709
Score:  0.801
Data Source:  STRINGDB
GTPBP1
Tbio
Novelty:  0.00160825
Score:  0.731
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
LDL clearance (R-HSA-8964038)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
LDL clearance
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein clearance
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
LDL clearance
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein clearance
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (40)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
3
9
95.8
body mass index
8
5
10
95.8
reticulocyte measurement
3
2
6
93
neutrophil count
3
2
3
81
high density lipoprotein cholesterol measurement
2
2
2
80.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
9
95.8
body mass index
10
95.8
reticulocyte measurement
6
93
neutrophil count
3
81
high density lipoprotein cholesterol measurement
2
80.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NPC intracellular cholesterol transporter 1
VGNC:10461
455338
Macaque
NPC intracellular cholesterol transporter 1
700835
Mouse
MGI:1097712
18145
Rat
RGD:628693
266732
Dog
NPC intracellular cholesterol transporter 1
VGNC:43913
403698
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NPC intracellular cholesterol transporter 1
Macaque
NPC intracellular cholesterol transporter 1
Mouse
Rat
Dog
NPC intracellular cholesterol transporter 1
Publication Statistics
PubMed Score 806.09
PubMed score by year
PubTator Score 642.23
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title