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Tchem
NPBWR1
Neuropeptides B/W receptor type 1

Protein Summary
Description
Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331251
  • ENSP00000330284
  • ENSG00000183729

Symbol
  • GPR7
  • GPR7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.6
protein domain
0.58
histone modification site profile
0.57
cell line
0.56
tissue
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.81   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.81   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (248)
NPW
Tbio
Novelty:  0.03174263
Score:  0.994
Data Source:  Reactome,STRINGDB
NPB
Tdark
Novelty:  0.00936692
Score:  0.992
Data Source:  Reactome,STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.956
Data Source:  STRINGDB
GAL
Tbio
Novelty:  0.0005132
Score:  0.949
Data Source:  STRINGDB
SST
Tbio
Novelty:  0.00005944
Score:  0.946
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.939
Data Source:  STRINGDB
GABBR2
Tclin
Family:  GPCR
Novelty:  0.00739771
Score:  0.934
Data Source:  STRINGDB
PDYN
Tbio
Novelty:  0.00039564
Score:  0.929
Data Source:  STRINGDB
RLN3
Tbio
Novelty:  0.0107593
Score:  0.923
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuropeptides B and W receptor 1
VGNC:14637
739992
Macaque
neuropeptides B and W receptor 1
710519
Mouse
MGI:891989
226304
Rat
RGD:1305917
297795
Dog
neuropeptides B and W receptor 1
VGNC:43912
486949
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuropeptides B and W receptor 1
Macaque
neuropeptides B and W receptor 1
Mouse
Rat
Dog
neuropeptides B and W receptor 1
Publication Statistics
PubMed Score 31.81
PubMed score by year
PubTator Score 17.19
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title