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Tbio
NPAT
Protein NPAT

Protein Summary
Description
Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278612
  • ENSP00000278612
  • ENSG00000149308

Symbol
  • CAND3
  • E14
  • E14
  • p220
  • E14/NPAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
cell type or tissue
0.72
transcription factor binding site profile
0.71
cellular component
0.64
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.22   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.22   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.999999811
p_ni:  1.89e-7
Data Source:  BioPlex
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999999562
p_ni:  4.38e-7
Score:  0.205
Data Source:  BioPlex,STRINGDB
HCCS
Tbio
Family:  Enzyme
Novelty:  0.0022585
p_int:  0.999999379
p_ni:  6.21e-7
Score:  0.353
Data Source:  BioPlex,STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
p_int:  0.999995173
p_ni:  0.000004828
Score:  0.412
Data Source:  BioPlex,STRINGDB
CRAMP1
Tdark
Novelty:  0.26519971
p_int:  0.999994322
p_ni:  0.000005678
Score:  0.571
Data Source:  BioPlex,STRINGDB
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.999871938
p_ni:  0.000128062
Score:  0.543
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999196626
p_ni:  0.000803374
Score:  0.258
Data Source:  BioPlex,STRINGDB
VPS39
Tbio
Novelty:  0.02172601
p_int:  0.998452712
p_ni:  0.001547288
Score:  0.187
Data Source:  BioPlex,STRINGDB
PIAS4
Tbio
Family:  TF
Novelty:  0.01388547
p_int:  0.993814508
p_ni:  0.006180792
p_wrong:  0.0000047
Data Source:  BioPlex
ASB8
Tdark
Novelty:  0.44680949
p_int:  0.987800604
p_ni:  0.009640143
p_wrong:  0.002559252
Score:  0.295
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Retinoblastoma Gene in Cancer
WikiPathways
Retinoblastoma Gene in Cancer
WikiPathways
Retinoblastoma Gene in Cancer
WikiPathways
Retinoblastoma Gene in Cancer
WikiPathways
Trans-sulfuration and one carbon metabolism
Name
Explore in Pharos
Explore in Source
Retinoblastoma Gene in Cancer
Retinoblastoma Gene in Cancer
Retinoblastoma Gene in Cancer
Retinoblastoma Gene in Cancer
Trans-sulfuration and one carbon metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
93.4
eosinophil percentage of leukocytes
2
2
2
85.2
mean corpuscular volume
1
1
1
78
platelet crit
1
1
1
77.9
platelet count
2
2
2
77.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
93.4
eosinophil percentage of leukocytes
2
85.2
mean corpuscular volume
1
78
platelet crit
1
77.9
platelet count
2
77.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear protein, coactivator of histone transcription
VGNC:8189
451529
Macaque
nuclear protein, ataxia-telangiectasia locus
707873
Mouse
MGI:107605
244879
Rat
RGD:1311947
315666
Dog
nuclear protein, coactivator of histone transcription
VGNC:50638
489420
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear protein, coactivator of histone transcription
Macaque
nuclear protein, ataxia-telangiectasia locus
Mouse
Rat
Dog
nuclear protein, coactivator of histone transcription
Publication Statistics
PubMed Score 92.22
PubMed score by year
PubTator Score 116.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title