NPAS1
Neuronal PAS domain-containing protein 1
Protein Summary
May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity). Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (By similarity). The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008]
- ENST00000439365
- ENSP00000398689
- ENSG00000130751
- ENST00000449844
- ENSP00000405290
- ENST00000602212
- ENSP00000469142
- BHLHE11
- MOP5
- PASD5
- MOP5
- PASD5
- bHLHe11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.91 | ||
cell type or tissue | 0.81 | ||
protein domain | 0.73 | ||
PubMedID | 0.68 | ||
biological process | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.04 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 177 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.04 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 177 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0