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Tbio
NPAS1
Neuronal PAS domain-containing protein 1

Protein Summary
Description
May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity). Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (By similarity). The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000439365
  • ENSP00000398689
  • ENSG00000130751
  • ENST00000449844
  • ENSP00000405290
  • ENST00000602212
  • ENSP00000469142

Symbol
  • BHLHE11
  • MOP5
  • PASD5
  • MOP5
  • PASD5
  • bHLHe11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
cell type or tissue
0.81
protein domain
0.73
PubMedID
0.68
biological process
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.18   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.18   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
ARNT
Tbio
Family:  TF
Novelty:  0.00183071
p_int:  0.999999992
p_ni:  8e-9
Score:  0.784
Data Source:  BioPlex,STRINGDB
ARNT2
Tbio
Family:  TF
Novelty:  0.01485424
p_int:  0.999998571
p_ni:  0.000001429
Score:  0.565
Data Source:  BioPlex,STRINGDB
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999826945
p_ni:  0.000173055
Data Source:  BioPlex
SMG7
Tbio
Novelty:  0.03394393
p_int:  0.999002021
p_ni:  0.000997952
p_wrong:  2.8e-8
Data Source:  BioPlex
AKAP1
Tbio
Family:  Epigenetic
Novelty:  0.00437217
p_int:  0.998724479
p_ni:  0.001275521
Score:  0.638
Data Source:  BioPlex,STRINGDB
ATG2B
Tbio
Novelty:  0.04963717
p_int:  0.998224373
p_ni:  0.001775625
p_wrong:  2e-9
Data Source:  BioPlex
PRUNE1
Tchem
Novelty:  0.02136836
p_int:  0.990548757
p_ni:  0.009429855
p_wrong:  0.000021387
Score:  0.163
Data Source:  BioPlex,STRINGDB
CRYBG3
Tdark
Family:  Enzyme
Novelty:  0.24063491
p_int:  0.990331888
p_ni:  0.007027354
p_wrong:  0.002640758
Score:  0.187
Data Source:  BioPlex,STRINGDB
DNAJB5
Tbio
Novelty:  0.20703358
p_int:  0.965165912
p_ni:  0.034832042
p_wrong:  0.000002045
Score:  0.485
Data Source:  BioPlex,STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
p_int:  0.931267492
p_ni:  0.068732507
Score:  0.162
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
3
3
93.3
body mass index
12
5
17
93
hemoglobin measurement
3
3
3
92.2
leukocyte count
2
2
2
80.6
body height
1
1
1
78.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
93.3
body mass index
17
93
hemoglobin measurement
3
92.2
leukocyte count
2
80.6
body height
1
78.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuronal PAS domain protein 1
VGNC:2301
746537
Macaque
neuronal PAS domain protein 1
716963
Mouse
MGI:109205
18142
Rat
RGD:1310040
308387
Dog
neuronal PAS domain protein 1
VGNC:43908
484424
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuronal PAS domain protein 1
Macaque
neuronal PAS domain protein 1
Mouse
Rat
Dog
neuronal PAS domain protein 1
Publication Statistics
PubMed Score 12.18
PubMed score by year
PubTator Score 3.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title