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Tdark
NOXRED1
NADP-dependent oxidoreductase domain-containing protein 1

Protein Summary
Description
Probable oxidoreductase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380835
  • ENSP00000370215
  • ENSG00000165555

Symbol
  • C14orf148
  • C14orf148
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
tissue sample
0.69
tissue
0.56
cell line
0.48
cellular component
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.54   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.54   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
MPZL1
Tbio
Novelty:  0.03292508
p_int:  0.987035647
p_ni:  0.01296428
p_wrong:  7.3e-8
Score:  0.507
Data Source:  BioPlex,STRINGDB
ALDH18A1
Tbio
Family:  Enzyme
Novelty:  0.00301673
Score:  0.798
Data Source:  STRINGDB
C14orf178
Tdark
Novelty:  4.43478261
Score:  0.765
Data Source:  STRINGDB
SAMD15
Tdark
Novelty:  4.50506694
Score:  0.731
Data Source:  STRINGDB
TMED8
Tdark
Novelty:  1.41977071
Score:  0.68
Data Source:  STRINGDB
ADCK1
Tchem
Family:  Kinase
Novelty:  0.31158074
Score:  0.668
Data Source:  STRINGDB
ISM2
Tdark
Novelty:  0.03660434
Score:  0.574
Data Source:  STRINGDB
VIPAS39
Tbio
Novelty:  0.02348642
Score:  0.572
Data Source:  STRINGDB
SLIRP
Tbio
Novelty:  0.04630917
Score:  0.516
Data Source:  STRINGDB
CSNK1A1
Tchem
Family:  Kinase
Novelty:  0.00636472
Score:  0.509
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
85
myeloid white cell count
2
2
2
74.7
leukocyte count
2
2
2
67.5
granulocyte count
1
1
1
54.4
sum of neutrophil and eosinophil counts
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
85
myeloid white cell count
2
74.7
leukocyte count
2
67.5
granulocyte count
1
54.4
sum of neutrophil and eosinophil counts
1
54.4
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADP dependent oxidoreductase domain containing 1
VGNC:12566
743729
Mouse
MGI:1918525
71275
Rat
RGD:1589353
681924
Horse
NADP dependent oxidoreductase domain containing 1
VGNC:20826
106780834
Cow
NADP dependent oxidoreductase domain containing 1
VGNC:32188
515802
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADP dependent oxidoreductase domain containing 1
Mouse
Rat
Horse
NADP dependent oxidoreductase domain containing 1
Cow
NADP dependent oxidoreductase domain containing 1
Publication Statistics
PubMed Score 0.54
PubMed score by year
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Related Publications
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PMID
Year
Title