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Tbio
NOXA1
NADPH oxidase activator 1

Protein Summary
Description
Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341349
  • ENSP00000342848
  • ENSG00000188747
  • ENST00000392815
  • ENSP00000376562

Symbol
  • P51NOX
  • p51NOX
  • NY-CO-31
  • SDCCAG31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
kinase
0.81
histone modification site profile
0.76
cell line
0.63
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.98   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.98   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
NOXO1
Tbio
Family:  Enzyme
Novelty:  0.02648748
Score:  0.995
Data Source:  Reactome,STRINGDB
NOX1
Tchem
Family:  Enzyme
Novelty:  0.0016839
Score:  0.993
Data Source:  Reactome,STRINGDB
NCF1
Tbio
Novelty:  0.00120288
Score:  0.991
Data Source:  Reactome,STRINGDB
NOX3
Tbio
Family:  Enzyme
Novelty:  0.01350666
Score:  0.98
Data Source:  Reactome,STRINGDB
CYBA
Tbio
Novelty:  0.00177762
Score:  0.979
Data Source:  Reactome,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.972
Data Source:  Reactome,STRINGDB
CYBB
Tchem
Family:  IC
Novelty:  0.00054866
Score:  0.939
Data Source:  STRINGDB
NCF4
Tbio
Novelty:  0.00560244
Score:  0.923
Data Source:  STRINGDB
NCF2
Tbio
Novelty:  0.00274685
Score:  0.918
Data Source:  STRINGDB
NOX4
Tchem
Family:  Enzyme
Novelty:  0.0009803
Score:  0.837
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (145)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate NADPH Oxidases
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases Activate NADPH Oxidases
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
4
2
3
1.1
90.8
mathematical ability
4
2
4
85.2
self reported educational attainment
1
1
1
72.6
insomnia measurement
1
1
0
1.1
62.8
cognitive function measurement
1
1
1
60.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
1.1
90.8
mathematical ability
4
85.2
self reported educational attainment
1
72.6
insomnia measurement
0
1.1
62.8
cognitive function measurement
1
60.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NADPH oxidase activator 1
721516
Mouse
MGI:2449980
241275
Rat
RGD:1306687
311793
Dog
NADPH oxidase activator 1 [Source:HGNC Symbol;Acc:HGNC:10668]
Horse
NADPH oxidase activator 1
VGNC:20825
100059408
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NADPH oxidase activator 1
Mouse
Rat
Dog
NADPH oxidase activator 1 [Source:HGNC Symbol;Acc:HGNC:10668]
Horse
NADPH oxidase activator 1
Publication Statistics
PubMed Score 26.98
PubMed score by year
PubTator Score 20.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title